Williams M C, Olsen J D
Am J Vet Res. 1984 Mar;45(3):539-42.
Seeds of horse chestnut (Aesculus hippocastanum), Ohio buckeye (A glabra), and yellow buckeye (A octandra) were tested for toxicity to 2-week-old Leghorn chicks and adult female Syrian hamsters. The LD50 of the water soluble portion of alcoholic extracts of horse-chestnut seeds (for hamsters and chicks) and of dried, powdered seeds (chicks only) was determined. The LD50 for a single dose of extract from horse-chestnut seeds was 10.6 mg/g of body weight for chicks and 10.7 mg/g of body weight for hamsters. The LD50 for chicks given 2 consecutive daily doses of horse-chestnut seed was 6.5 mg/g. Toxic signs included depression, muscular incoordination, paralysis, coma, and death. Extracts of seeds of Ohio buckeye were nontoxic to chicks and hamsters when fed at 80 mg/g. One of 5 hamsters died after dosing for 5 days with 80 mg/g of extract of seeds of yellow buckeye/g.
对七叶树（欧洲七叶树）、俄亥俄七叶树和黄花七叶树的种子进行了对2周龄来亨鸡和成年雌性叙利亚仓鼠的毒性测试。测定了七叶树种子酒精提取物水溶性部分（对仓鼠和鸡）以及干燥的种子粉末（仅对鸡）的半数致死量（LD50）。七叶树种子提取物单剂量对鸡的LD50为10.6毫克/克体重，对仓鼠为10.7毫克/克体重。连续两天给鸡投喂七叶树种子，其LD50为6.5毫克/克。中毒症状包括抑郁、肌肉不协调、瘫痪、昏迷和死亡。以80毫克/克的量投喂时，俄亥俄七叶树种子提取物对鸡和仓鼠无毒。用80毫克/克黄花七叶树种子提取物给5只仓鼠连续投喂5天，其中1只死亡。
