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热休克样蛋白从神经胶质细胞转移至轴突。

Heat shock-like protein is transferred from glia to axon.

作者信息

Tytell M, Greenberg S G, Lasek R J

出版信息

Brain Res. 1986 Jan 15;363(1):161-4. doi: 10.1016/0006-8993(86)90671-2.

DOI:10.1016/0006-8993(86)90671-2
PMID:3947949
Abstract

Glia-axon protein transfer was examined in the squid giant axon. Proteins synthesized by the glial sheath surrounding the axon were labeled with [3H]leucine. Raising the temperature of the incubation medium from 20 degrees C to 30 degrees C increased the synthesis of glial proteins that resembled heat-shock proteins. These proteins were among the group known to be transferred into the axon. Thus, glia provide the axon with proteins that may be involved in the reaction to trauma.

摘要

在枪乌贼的巨大轴突中研究了神经胶质细胞-轴突蛋白转移。用[³H]亮氨酸标记围绕轴突的神经胶质鞘合成的蛋白质。将孵育培养基的温度从20℃提高到30℃,增加了类似于热休克蛋白的神经胶质蛋白的合成。这些蛋白质属于已知会转移到轴突中的蛋白质组。因此,神经胶质细胞为轴突提供了可能参与创伤反应的蛋白质。

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1
Heat shock-like protein is transferred from glia to axon.热休克样蛋白从神经胶质细胞转移至轴突。
Brain Res. 1986 Jan 15;363(1):161-4. doi: 10.1016/0006-8993(86)90671-2.
2
Glial polypeptides transferred into the squid giant axon.转移至鱿鱼巨大轴突中的神经胶质多肽。
Brain Res. 1984 Dec 24;324(2):223-32. doi: 10.1016/0006-8993(84)90032-5.
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Cell-to-cell transfer of glial proteins to the squid giant axon. The glia-neuron protein trnasfer hypothesis.胶质蛋白向鱿鱼巨轴突的细胞间转移。胶质-神经元蛋白转移假说。
J Cell Biol. 1977 Aug;74(2):501-23. doi: 10.1083/jcb.74.2.501.
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Evidence for the glia-neuron protein transfer hypothesis from intracellular perfusion studies of squid giant axons.来自鱿鱼巨大轴突细胞内灌注研究的神经胶质细胞-神经元蛋白质转移假说的证据。
J Cell Biol. 1977 Aug;74(2):524-30. doi: 10.1083/jcb.74.2.524.
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Axon-glia exchange of macromolecules.轴突与神经胶质之间的大分子交换。
Ann N Y Acad Sci. 1991;633:318-30. doi: 10.1111/j.1749-6632.1991.tb15623.x.
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Transfer of molecules from glia to axon in the squid may be mediated by glial vesicles.在鱿鱼中,分子从神经胶质细胞向轴突的转移可能由神经胶质小泡介导。
J Neurobiol. 1992 Apr;23(3):217-30. doi: 10.1002/neu.480230303.
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Transfer of newly synthesized proteins from Schwann cells to the squid giant axon.新合成蛋白质从施万细胞向乌贼巨大轴突的转移。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1188-92. doi: 10.1073/pnas.71.4.1188.
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Selective release from cultured mammalian cells of heat-shock (stress) proteins that resemble glia-axon transfer proteins.从培养的哺乳动物细胞中选择性释放类似于神经胶质-轴突转运蛋白的热休克(应激)蛋白。
J Cell Physiol. 1989 Feb;138(2):257-66. doi: 10.1002/jcp.1041380206.
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Glia-to-axon communication: enrichment of glial proteins transferred to the squid giant axon.胶质细胞与轴突的通讯:转移至乌贼巨大轴突的胶质蛋白富集
J Neurosci Res. 1995 Jun 15;41(3):324-34. doi: 10.1002/jnr.490410305.
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Squid Giant Axon Contains Neurofilament Protein mRNA but does not Synthesize Neurofilament Proteins.鱿鱼巨轴突含有神经丝蛋白信使核糖核酸,但不合成神经丝蛋白。
Cell Mol Neurobiol. 2017 Apr;37(3):475-486. doi: 10.1007/s10571-016-0382-z. Epub 2016 May 20.

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