Nishino H, Oomura Y, Karádi Z, Lénárd L, Kai Y, Fukuda A, Ito C, Min B I, Salaman C P
Department of Biological Control System, National Institute for Physiological Sciences, Okazaki, Japan.
Brain Res Bull. 1988 Jun;20(6):839-45. doi: 10.1016/0361-9230(88)90100-1.
Single neuron activities in the lateral hypothalamic area (LHA) were recorded during bar press feeding task in the monkey. First registered neurons were sorted into 2 groups, glucose-sensitive (GS) and glucose-insensitive (GIS) neurons, depending on their glucose sensitivity. The firing variations to feeding, electrophoretically applied catecholamines and opiate, and to odor and taste stimuli were investigated. GS neurons responded to dopamine, noradrenaline and morphine more often than GIS neurons. In feeding task GS neurons responded during bar press (BP) and reward (RW) periods with long-lasting inhibition of firing and at cue tone (CT) with transient inhibition, while GIS neurons responded during BP and RW periods mainly with excitation and at cue light (CL) with excitation. A majority of GS neurons responded to both odor and taste stimuli more often than GIS neurons. Data suggest that these two kinds of neurons in the LHA may be involved in different functional aspects of feeding: GS neurons, mainly in internal information processing and reward mechanism, and GIS neurons, in external information processing and motor aspects.
在猴子进行压杆进食任务期间，记录了下丘脑外侧区（LHA）的单个神经元活动。首先，根据其葡萄糖敏感性，将记录到的神经元分为两组：葡萄糖敏感（GS）神经元和葡萄糖不敏感（GIS）神经元。研究了这些神经元对进食、电泳施加的儿茶酚胺和阿片类药物以及气味和味觉刺激的放电变化。与GIS神经元相比，GS神经元对多巴胺、去甲肾上腺素和吗啡的反应更频繁。在进食任务中，GS神经元在压杆（BP）和奖励（RW）期间以持续的放电抑制做出反应，在提示音（CT）时以短暂抑制做出反应，而GIS神经元在BP和RW期间主要以兴奋做出反应，在提示光（CL）时以兴奋做出反应。与GIS神经元相比，大多数GS神经元对气味和味觉刺激的反应更频繁。数据表明，LHA中的这两种神经元可能参与进食的不同功能方面：GS神经元主要参与内部信息处理和奖励机制，而GIS神经元参与外部信息处理和运动方面。
