神经发育过程中小胶质细胞的噬尸作用导致坏死性细胞死亡。
Microglia cannibalism during neurodevelopment results in necroptotic cell death.
机构信息
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
出版信息
PLoS Biol. 2024 Oct 31;22(10):e3002869. doi: 10.1371/journal.pbio.3002869. eCollection 2024 Oct.
Abstract
Clearance of dying neurons by microglia is critical to healthy neurodevelopment, but what else do microglia eat? A new study in PLOS Biology demonstrates that microglia not only eat neurons but each other, and that this "microglia cannibalism" causes necroptotic cell death.
摘要
小胶质细胞清除死亡神经元对于健康的神经发育至关重要，但小胶质细胞还吃什么呢？PLOS Biology 的一项新研究表明，小胶质细胞不仅吃神经元，还互相吞噬，这种“小胶质细胞自噬”会导致坏死性细胞死亡。
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