Chen Sheng-Yu, Tang Lu-Ning, Chen Ming
Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.
Org Lett. 2024 Nov 15;26(45):9799-9803. doi: 10.1021/acs.orglett.4c03873. Epub 2024 Oct 31.
Significant progress has been made in the synthesis of diverse ketals through a palladium-catalyzed reaction involving allylic -difluorides and various phenols or alcohols. This methodology facilitates double -defluoroetherification of allylic -difluorides, resulting in high product yields with excellent regioselectivity. The reactions were conducted under mild conditions and exhibited outstanding tolerance to a wide range of functional groups. Notably, this approach overcomes the traditional limitation of palladium-catalyzed processes, where nucleophiles typically target the common C-1 position of allylic -difluorides, enabling selective functionalization at the rare C-3 position instead.
通过钯催化的涉及烯丙基二氟化物与各种酚类或醇类的反应，在合成多种缩酮方面取得了重大进展。该方法促进了烯丙基二氟化物的双脱氟醚化反应，从而以优异的区域选择性实现了高产物收率。反应在温和条件下进行，对多种官能团表现出出色的耐受性。值得注意的是，这种方法克服了钯催化过程的传统局限性，在传统过程中亲核试剂通常靶向烯丙基二氟化物的常见C-1位，而此方法能够在罕见的C-3位实现选择性官能化。
