Research Unit of Clinical Medicine and Medical Research Centre Oulu, University of Oulu, Oulu, Finland.
Research Unit of Clinical Medicine and Medical Research Centre Oulu, University of Oulu, Oulu, Finland.
EBioMedicine. 2024 Nov;109:105426. doi: 10.1016/j.ebiom.2024.105426. Epub 2024 Oct 31.
Intrapartum antibiotics are used to prevent group B streptococcus disease in newborn infants. We hypothesised that intrapartum antibiotic exposure is associated with the occurrence of childhood infectious diseases because it influences the development of the gut microbiome.
The cohort for this population-based study comprised vaginally delivered children born in Northern Finland in 2007-2018. We used structured electronic medical records linked to comprehensive national registers. Primary outcome was the number of infectious disease episodes leading to an emergency room visit, outpatient hospital visit, or hospitalisation from birth until five years of age.
Analyses were performed on 9733 children (48.8% girls) exposed to intrapartum antibiotics and on 35,842 unexposed children (49.9% girls). Exposure to intrapartum antibiotics was associated with increased risk of any infectious disease episode at the ages 7-28 days (adjusted incidence rate ratio [aIRR] 1.30, 95% CI 1.10-1.54) and 1-2 years (aIRR 1.10, 95% CI 1.02-1.18). The occurrence of urinary tract infections was associated with the exposure to intrapartum antibiotics whereas the occurrence of severe infections caused by pathogens susceptible to penicillin was reversely associated with the exposure to intrapartum antibiotics.
Maternal intrapartum antibiotics were associated with the occurrence of infectious diseases in the offspring. The observed associations appeared to depend on bacterial pathogens and their antimicrobial susceptibility to penicillin.
Pediatric Research Foundation, Alma och K.A. Snellman Foundation, Orion Research Foundation, Päivikki and Sakari Sohlberg Foundation, Finnish Medical Foundation, Academy of Finland, Finland.
产时抗生素用于预防新生儿 B 组链球菌病。我们假设产时抗生素暴露与儿童传染病的发生有关，因为它会影响肠道微生物组的发育。
本基于人群的队列研究包括 2007 年至 2018 年在芬兰北部阴道分娩的儿童。我们使用结构化电子病历与全面的国家登记册相关联。主要结局是从出生到五岁时因传染病发作而导致急诊就诊、门诊就诊或住院的次数。
对 9733 名（48.8%为女孩）暴露于产时抗生素的儿童和 35842 名（49.9%为女孩）未暴露于抗生素的儿童进行了分析。产时抗生素暴露与 7-28 天（调整发病率比[aIRR]1.30，95%CI 1.10-1.54）和 1-2 岁（aIRR 1.10，95%CI 1.02-1.18）时任何传染病发作的风险增加相关。尿路感染的发生与产时抗生素暴露相关，而对青霉素敏感的病原体引起的严重感染的发生与产时抗生素暴露呈负相关。
母体产时抗生素与后代传染病的发生有关。观察到的关联似乎取决于细菌病原体及其对青霉素的药敏性。
儿科研究基金会、Alma och K.A. Snellman 基金会、猎户座研究基金会、Päivikki 和 Sakari Sohlberg 基金会、芬兰医学基金会、芬兰科学院、芬兰。
