光动力疗法在复发性生殖器疱疹中的应用。

The application of photodynamic therapy in recurrent genital herpes.

作者信息

Chen Jinyi, Li Yuancheng, Li Dechao, Chen Nian, Ding Wen, Zou Ting, Tan Yang, Lei Xia

机构信息

Department of Dermatology, Daping Hospital, Army Medical University(Third Military Medical University), No.10, Yangtze River Branch Road, Daping, Yuzhong District, Chongqing, 400042, China; Research Center for Skin Tissue Engineering of Chongqing Higher Education Institutions, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China; Engineering Research Center of the Ministry of Education for Tissue and Organ Regeneration and Manufacturing, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.

出版信息

Photodiagnosis Photodyn Ther. 2024 Dec;50:104386. doi: 10.1016/j.pdpdt.2024.104386. Epub 2024 Oct 30.

DOI:10.1016/j.pdpdt.2024.104386

PMID:39481741

Abstract

BACKGROUND

Frequently, recurrence of genital herpes imposes significant physical and psychological burdens on patients, and existing treatments are often ineffective in preventing recurrence. Previous studies have indicated that photodynamic therapy (PDT) showed promising outcomes in the treatment of labial herpes simplex virus (HSV) infections; however, its efficacy for genital herpes remained unclear.

METHOD

The study screened patients with genital herpes at Daping Hospital from July 2020 to May 2024. Patients were divided into two groups based on whether they received PDT treatment. Over a one-year follow-up period, patients' healing time and recurrence rates were compared between the two groups. The cumulative incidence of recurrence and restricted mean survival time (RMST) were used to assess outcomes. Propensity score matching (PSM) was employed to minimize bias.

RESULT

A total of 41 patients enrolled in our study, with 8 (19.5 %) received PDT. The non-PDT group exhibited a slower skin lesion healing time, averaging at 7.2 days compared to 5.4 days in the PDT group. A significant difference was observed in the cumulative incidence of recurrence between the PDT and non-PDT groups (37.5 % versus 71.4 %) after PSM. The RMST in the PDT group was 9.94 days, compared to 5.13 days in the non-PDT group before PSM, and 4.14 after PSM.

CONCLUSION

Our study demonstrated that the PDT effectively reduced lesion recovery time and delayed recurrences of genital herpes. We recommend considering PDT as a potential treatment option for patients with recurrent genital herpes.

摘要

背景

生殖器疱疹的复发常常给患者带来巨大的身心负担，并且现有的治疗方法在预防复发方面往往效果不佳。先前的研究表明，光动力疗法（PDT）在治疗唇疱疹单纯病毒（HSV）感染方面显示出有前景的结果；然而，其对生殖器疱疹的疗效仍不明确。

方法

该研究对2020年7月至2024年5月在大坪医院的生殖器疱疹患者进行了筛查。根据患者是否接受PDT治疗将其分为两组。在一年的随访期内，比较两组患者的愈合时间和复发率。采用复发的累积发生率和受限平均生存时间（RMST）来评估结果。使用倾向得分匹配（PSM）来最小化偏差。

结果

共有41名患者纳入我们的研究，其中8名（19.5%）接受了PDT治疗。非PDT组的皮肤病变愈合时间较慢，平均为7.2天，而PDT组为5.4天。PSM后，PDT组和非PDT组之间的复发累积发生率存在显著差异（37.5%对71.4%）。PDT组的RMST为9.94天，PSM前非PDT组为5.13天，PSM后为4.14天。