Monte Andrea, Vilimek Dominik, Uchytil Jaroslav, Skypala Jiri, Cipryan Lukáš, Casula Victor, Jandačka Daniel, Nieminen Miika T
Human Motion Diagnostic Center, Department of Human Movement Studies, University of Ostrava, 70200, Ostrava, Czech Republic.
Departments of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Eur J Appl Physiol. 2025 Mar;125(3):885-894. doi: 10.1007/s00421-024-05646-5. Epub 2024 Nov 1.
In an asymptomatic population, we investigated the relationships between glycated haemoglobin (HbA1c) and cartilage T2 relaxation time at the knee joint level. Fourteen and 17 participants with high and normal levels of HbA1c were recruited, respectively. A blood sample was used to determine the HbA1c level. T2 relaxation time (T2) of the superficial and deep parts of the femoral cartilage in the anterior, central, and posterior topographical sites was calculated using magnetic resonance (1.5 T) images. Each participant completed a knee injury and osteoarthritis outcome score questionnaire (KOOS) and a series of biomechanical analyses while running at their self-selected speed. The group with a high level of HbA1c had a lower score of KOOS symptoms than the other group (P < 0.05). HbA1c was found to be negatively related to the KOOS symptoms score. The group with a high level of HbA1c had low T2 values in all of the investigated topographical sites of the knee femoral cartilage (P < 0.05 in all cases). T2 was negatively correlated with HbA1c levels in all investigated knee femoral cartilage regions. Our data suggest that the subjects with high levels of HbA1c were those with low knee joint symptoms and lower values of T2. These results indicate that HbA1c could be correlated with cartilage deterioration due to its ability to dehydrate collagen fibre, possibly acting as a risk factor for the development of osteoarthritis.
在无症状人群中，我们研究了糖化血红蛋白（HbA1c）与膝关节水平软骨T2弛豫时间之间的关系。分别招募了14名HbA1c水平高和17名HbA1c水平正常的参与者。采集血样以测定HbA1c水平。利用磁共振（1.5T）图像计算股骨软骨前、中、后三个部位表层和深层的T2弛豫时间（T2）。每位参与者在以自己选择的速度跑步时完成了膝关节损伤和骨关节炎疗效评分问卷（KOOS）以及一系列生物力学分析。HbA1c水平高的组的KOOS症状评分低于另一组（P<0.05）。发现HbA与KOOS症状评分呈负相关。HbA1c水平高的组在所有研究的膝关节股骨软骨部位的T2值均较低（所有情况P<0.05）。在所有研究的膝关节股骨软骨区域，T2与HbA1c水平呈负相关。我们的数据表明，HbA1c水平高的受试者是膝关节症状少且T2值低的人。这些结果表明，HbA1c可能因其使胶原纤维脱水的能力而与软骨退变相关，可能是骨关节炎发展的一个危险因素。
