Zhai Keran, Rhodes Jack, Zipfel Cyril
Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland.
The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK.
Nat Plants. 2024 Dec;10(12):2027-2037. doi: 10.1038/s41477-024-01840-7. Epub 2024 Oct 31.
Plants employ cell-surface receptors to perceive non- or altered-self, including the integrity of their cell wall. Here we identify a specific ligand-receptor module responsive to cell wall damage that potentiates immunity in Arabidopsis. Disruption of cell wall integrity by inhibition of cellulose biosynthesis promotes pattern-triggered immunity transcriptionally in a manner dependent on the receptor kinase MALE DISCOVERER 1-INTERACTING RECEPTOR-LIKE KINASE 2 (MIK2). Notably, while MIK2 can perceive peptides of the large SERINE RICH ENDOGENOUS PEPTIDE family, a single member of this family, SCOOP18, is transcriptionally induced upon cell wall damage and is required for subsequent responses such as lignification and immunity potentiation. Collectively, our results identify the SCOOP18-MIK2 ligand-receptor module as an important central hub, connecting plant cell wall integrity sensing with immunity.
植物利用细胞表面受体来感知非自身或改变的自身，包括其细胞壁的完整性。在这里，我们鉴定了一个对细胞壁损伤有反应的特定配体-受体模块，该模块可增强拟南芥的免疫力。通过抑制纤维素生物合成破坏细胞壁完整性，以依赖于受体激酶雄性发现者1相互作用受体样激酶2（MIK2）的方式转录促进模式触发的免疫。值得注意的是，虽然MIK2可以感知富含丝氨酸的大型内源性肽家族的肽，但该家族的单个成员SCOOP18在细胞壁损伤时会被转录诱导，并且是后续反应如木质化和免疫增强所必需的。总之，我们的结果确定了SCOOP18-MIK2配体-受体模块是一个重要的中心枢纽，将植物细胞壁完整性感知与免疫联系起来。
