Department of Infectious Diseases, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, 12 Changjia Lane, Jingzhong Street, Fucheng District, Mianyang, Sichuan, China.
Department of Pathology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, China.
BMC Infect Dis. 2024 Oct 31;24(1):1226. doi: 10.1186/s12879-024-10144-2.
Prostatic malakoplakia is an uncommon chronic inflammatory disorder, tumor-like but non-cancerous, the diagnosis of which pivots crucially on the identification of characteristic Michaelis-Gutmann bodies within the pathological tissue. We hereby present an inaugural case report of prostatic malakoplakia concurrent with sepsis caused by multidrug-resistant Escherichia coli, verified through blood culture and metagenomic next-generation sequencing (mNGS). The pathogenesis might be associated with infections by Escherichia coli, immune system irregularities, or lysosomal dysfunction. Although the patient had no chronic underlying diseases, he presented early with sepsis and multi-organ dysfunction. This case emphasizes the imperative to further investigate the association between malakoplakia and Escherichia coli, the necessity for prompt diagnosis, and the supportive role of mNGS, and the treatment strategy focuses on rapid control of infection and systemic inflammatory response.
前列腺软斑病是一种不常见的慢性炎症性疾病，表现为肿瘤样但非癌性，其诊断的关键在于在病理组织中发现特征性的米氏-古特曼小体。我们在此首次报告一例前列腺软斑病并发多药耐药大肠杆菌引起的败血症，通过血培养和宏基因组二代测序（mNGS）证实。发病机制可能与大肠杆菌感染、免疫系统异常或溶酶体功能障碍有关。虽然患者没有慢性基础疾病，但他早期即出现败血症和多器官功能障碍。本病例强调了进一步研究软斑病与大肠杆菌之间的关系、及时诊断的必要性以及 mNGS 的支持作用的必要性，治疗策略侧重于快速控制感染和全身炎症反应。
