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关于《肯尼亚监狱囚犯中结核病与艾滋病毒合并感染的患病率及危险因素》的评论

Comments on: prevalence and risk factors for tuberculosis and HIV coinfections in Kenyan prison inmates.

作者信息

Hamza Muhammad, Jalil Zil-E-Huma, Sattar Abid Jan Abdul, Sohail Hamnah, Oduoye Malik Olatunde

机构信息

Department of Internal Medicine, Saidu Medical College, Swat, Pakistan.

Department of Internal Medicine, Sahiwal Medical College, Sahiwal, Pakistan.

出版信息

Trop Med Health. 2024 Oct 31;52(1):78. doi: 10.1186/s41182-024-00650-z.

DOI:10.1186/s41182-024-00650-z
PMID:39482708
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11528985/
Abstract

The study by Mwatenga et al. found a tuberculosis (TB) prevalence of 10.2% and an HIV prevalence of 19.1% among inmates, with all TB cases co-infected with HIV. Education level, smoking history, and substance use are key predictors of coinfections. Although informative, its single-centred design and reliance on sputum samples may be insufficient for some patient groups, potentially compromising diagnostic accuracy. Expanding the study to include several jails and employing more diagnostic procedures may increase reliability and the ability to generalize. The report also notes the lack of debate on broader socioeconomic variables and structural barriers to healthcare in jails, which are crucial to understanding inmates' health challenges. Overcrowding, malnutrition, and a poor healthcare system are examples of environmental factors that probably contribute to the spread of tuberculosis and make managing HIV more difficult. Additionally, not enough is known about the dietary habits of prisoners and other health conditions like diabetes or mental health, which may have an impact on the course of HIV and TB. Future studies should take these extra characteristics into account to create more comprehensive approaches to controlling HIV coinfections and TB in prison populations. This will help build more effective therapies.

摘要

姆瓦滕加等人的研究发现,囚犯中的结核病患病率为10.2%,艾滋病毒患病率为19.1%,所有结核病病例均合并感染艾滋病毒。教育水平、吸烟史和药物使用是合并感染的关键预测因素。尽管该研究提供了信息,但它的单中心设计以及对痰液样本的依赖,对于某些患者群体可能并不充分,这可能会影响诊断准确性。将研究扩展到多个监狱并采用更多诊断程序,可能会提高可靠性和推广能力。该报告还指出,对于监狱中更广泛的社会经济变量以及医疗保健的结构性障碍缺乏讨论,而这些对于理解囚犯的健康挑战至关重要。过度拥挤、营养不良和糟糕的医疗系统都是可能导致结核病传播并使艾滋病毒管理更加困难的环境因素。此外,对于囚犯的饮食习惯以及糖尿病或心理健康等其他健康状况了解不足,这些可能会影响艾滋病毒和结核病的病程。未来的研究应考虑这些额外特征,以制定更全面的方法来控制监狱人群中的艾滋病毒合并感染和结核病。这将有助于建立更有效的治疗方法。

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本文引用的文献

1
Prevalence and associated factors of TB and HIV coinfections among adult inmates with presumptive pulmonary TB in a Kenyan prison.肯尼亚一所监狱中推定患有肺结核的成年囚犯中结核病与艾滋病毒合并感染的患病率及相关因素
Trop Med Health. 2024 Aug 16;52(1):54. doi: 10.1186/s41182-024-00623-2.
2
Diabetes mellitus is associated with an increased risk of unsuccessful treatment outcomes among drug-susceptible tuberculosis patients in Ethiopia: A prospective health facility-based study.糖尿病与埃塞俄比亚药物敏感型肺结核患者治疗结果不佳的风险增加有关:一项基于医疗机构的前瞻性研究。
J Clin Tuberc Other Mycobact Dis. 2023 Apr 11;31:100368. doi: 10.1016/j.jctube.2023.100368. eCollection 2023 May.
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Tuberculosis and malnutrition: The European perspective.结核病与营养不良:欧洲视角
Clin Nutr. 2023 Apr;42(4):486-492. doi: 10.1016/j.clnu.2023.01.016. Epub 2023 Feb 10.
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Tuberculosis related disability: a systematic review and meta-analysis.结核病相关残疾:系统评价和荟萃分析。
BMC Med. 2021 Sep 9;19(1):203. doi: 10.1186/s12916-021-02063-9.
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An alternative method for sputum storage and transport for mycobacterium tuberculosis drug resistance surveys.一种用于结核分枝杆菌耐药性调查的痰液储存和运输的替代方法。
Int J Tuberc Lung Dis. 2006 Feb;10(2):172-7.
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Viability of stored sputum specimens for smear microscopy and culture.储存痰液标本用于涂片显微镜检查和培养的可行性。
Int J Tuberc Lung Dis. 2000 Mar;4(3):272-4.