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当归芍药散对肠道菌群的调节作用及其改善阿尔茨海默病模型小鼠认知功能障碍的相关性研究。

Correlation Between Regulation of Intestinal Flora by Danggui-Shaoyao-San and Improvement of Cognitive Impairment in Mice With Alzheimer's Disease.

机构信息

Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.

The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.

出版信息

Brain Behav. 2024 Nov;14(11):e70110. doi: 10.1002/brb3.70110.

DOI:10.1002/brb3.70110
PMID:39482855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11527834/
Abstract

PURPOSE

The abnormal central glucose metabolism in Alzheimer's disease (AD) is related to the brain-gut axis. This study aims to explore the target of Danggui-Shaoyao-San (DSS) in improving cognitive impairment.

METHOD

This study analyzed the differences in mice intestinal flora by 16S rRNA sequencing. The cognitive protective effects of DSS were observed through the Morris water maze and the new object recognition. The mitigation effects of DSS on Aβ and p-tau, regulatory effects on glucose metabolism targets, and intestinal structure effects were observed through brain and colon slices staining. The differences in neural ultrastructure were compared by transmission electron microscopy.

FINDING

The results showed that DSS affected the composition of intestinal dominant bacteria and bacteria genera and regulated the abundance of intestinal bacteria in AD mice. DSS improved the behavior of AD mice, alleviated the deposition of AD pathological products in the brain and colon, regulated the expression of glycometabolism-related proteins, and improved the colon barrier structure and neural ultrastructure in the brain of mice with AD.

CONCLUSION

Our findings suggest that DSS may affect AD central glucose metabolism and improve cognition by regulating the gut-brain axis.

摘要

目的

阿尔茨海默病（AD）中异常的中枢葡萄糖代谢与脑-肠轴有关。本研究旨在探讨当归芍药散（DSS）改善认知障碍的作用靶点。

方法

本研究通过 16S rRNA 测序分析了小鼠肠道菌群的差异。通过 Morris 水迷宫和新物体识别观察 DSS 的认知保护作用。通过脑和结肠切片染色观察 DSS 对 Aβ和 p-tau 的缓解作用、对葡萄糖代谢靶标的调节作用以及对肠道结构的影响。通过透射电子显微镜比较神经超微结构的差异。

结果

结果表明，DSS 影响了肠道优势菌和菌属的组成，并调节了 AD 小鼠肠道细菌的丰度。DSS 改善了 AD 小鼠的行为，减轻了 AD 病理产物在大脑和结肠中的沉积，调节了糖代谢相关蛋白的表达，改善了 AD 小鼠大脑中结肠屏障结构和神经超微结构。

结论

我们的研究结果表明，DSS 可能通过调节脑-肠轴影响 AD 中枢葡萄糖代谢并改善认知。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/3f3d2c03e9fa/BRB3-14-e70110-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/a79fef7c987b/BRB3-14-e70110-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/adcd3fa5db2a/BRB3-14-e70110-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/0a9f78c5f465/BRB3-14-e70110-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/d0f7fd8fc06c/BRB3-14-e70110-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/c8ae55ec05cb/BRB3-14-e70110-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/19b6f2f1923d/BRB3-14-e70110-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/968b01b92a1f/BRB3-14-e70110-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/4c0c254fa80c/BRB3-14-e70110-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/3f3d2c03e9fa/BRB3-14-e70110-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/a79fef7c987b/BRB3-14-e70110-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/adcd3fa5db2a/BRB3-14-e70110-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/0a9f78c5f465/BRB3-14-e70110-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/d0f7fd8fc06c/BRB3-14-e70110-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/c8ae55ec05cb/BRB3-14-e70110-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/19b6f2f1923d/BRB3-14-e70110-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/968b01b92a1f/BRB3-14-e70110-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/4c0c254fa80c/BRB3-14-e70110-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0165/11527834/3f3d2c03e9fa/BRB3-14-e70110-g004.jpg

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