Yilmaz Ozge, Onder Alev
Department of Pharmacognosy, Faculty of Pharmacy, Ankara University, 06100, Ankara, Türkiye.
Infect Disord Drug Targets. 2025;25(4):e18715265319110. doi: 10.2174/0118715265319110240916061200.
Tea is obtained from the young leaves and shoots of the evergreen perennial plant (L.) Kuntze, the most popular and frequently consumed product using a natural beverage worldwide. Some kinds of tea products, such as green tea, black tea, and oolong tea, have assorted flavors depending on the manufacturing techniques. Green tea has been studied for many years for its important beneficial effects, including anticancer, antiobesity, anti-diabetes, anti-inflammatory, neuroprotective, and cardiovascular effects. These effects are primarily associated with tea polyphenols, and regular consumption has been reported to decrease the incidence of some chronic diseases. Current studies support that green tea catechins play an important role in healing and improving the pathology of many diseases. Epigallocatechin-3-gallate (EGCG) is the most a highly found polyphenol in the leaves and is of great interest for its protective role in the prevention of diseases. Therefore, this review presents the efficacy and possible mechanisms of EGCG against sexually transmitted viruses. Moreover, EGCG and its derivatives are recognized as safe bioactive phytochemicals for external and internal use in preventing and treating viral STIs and other concurrent infections. Multidisciplinary studies are essential to discover cheaper, safer, and more effective treatments using EGCG and its derivatives to improve the toxicity and formulations of viral STI medications.
茶取自常绿多年生植物（L.）Kuntze的幼叶和嫩梢，是全球最受欢迎且饮用最为频繁的天然饮品。某些茶产品，如绿茶、红茶和乌龙茶，因其制作工艺不同而具有各异的风味。多年来，绿茶因其重要的有益功效而受到研究，这些功效包括抗癌、抗肥胖、抗糖尿病、抗炎、神经保护和心血管保护作用等。这些作用主要与茶多酚有关，据报道，经常饮用绿茶可降低某些慢性病的发病率。目前的研究证实，绿茶儿茶素在多种疾病的治愈和病理改善方面发挥着重要作用。表没食子儿茶素没食子酸酯（EGCG）是茶叶中含量最高的多酚，因其在疾病预防中的保护作用而备受关注。因此，本综述介绍了EGCG对抗性传播病毒的功效及可能机制。此外，EGCG及其衍生物被认为是安全的生物活性植物化学物质，可用于预防和治疗病毒性性传播感染及其他并发感染的内外用。多学科研究对于利用EGCG及其衍生物发现更廉价、更安全、更有效的治疗方法以改善病毒性性传播感染药物的毒性和剂型至关重要。
