Wang Linlin, Li Jialin, Wang Bo, Yin Xianglin, Wei Jinfeng, Qiu Hongbin
Jiamusi University, Jiamusi, Heilongjiang 154007, P.R. China.
Heilongjiang Provincial Key Laboratory of Gout Research, Jiamusi, Heilongjiang 154007, P.R. China.
Biomed Rep. 2024 Oct 14;22(1):1. doi: 10.3892/br.2024.1879. eCollection 2025 Jan.
Human organ tissue is vulnerable to hyperuricemia (HUA), which negatively impacts quality of life, particularly when it progresses to gout. Chicken uric acid formation and metabolism are similar to human uric acid metabolism; therefore, theoretically, the genesis and progression of human HUA and gout may be similar to those of poultry models. The present review explored HUA and gout and the progress of poultry-induced HUA and gout models. The present study reviewed procedures of modelling chicken gout and HUA and the detection indices and current concerns regarding these models. Notably, In the production of poultry hyperuricemia model, the combined method of water and food induction has a higher success rate and stability. Compared with mice induced HUA and gout models, poultry induced HUA and gout models had less kidney damage, and the models were stable and long-lasting.
人体器官组织易受高尿酸血症（HUA）影响，这会对生活质量产生负面影响，尤其是当病情发展为痛风时。鸡的尿酸形成和代谢与人类尿酸代谢相似；因此，从理论上讲，人类高尿酸血症和痛风的发生及发展可能与家禽模型相似。本综述探讨了高尿酸血症和痛风以及家禽诱导的高尿酸血症和痛风模型的研究进展。本研究回顾了鸡痛风和高尿酸血症模型的构建方法、检测指标以及对这些模型的当前关注点。值得注意的是，在家禽高尿酸血症模型的制作中，水和食物联合诱导法具有更高的成功率和稳定性。与小鼠诱导的高尿酸血症和痛风模型相比，家禽诱导的高尿酸血症和痛风模型对肾脏的损伤较小，且模型稳定持久。
