Zhou Hongyan, Yang Jingyi, Yuan Xiaoqing, Song Xinyu, Zhang Xingcai, Cao Ting, Zhang Jiayu
Institute of Chinese Medicine, Binzhou Medical University, Yantai, Shandong, China.
School of Pharmacy, University of TCM, Jinan, Shandong, China.
Front Pharmacol. 2024 Mar 7;15:1294755. doi: 10.3389/fphar.2024.1294755. eCollection 2024.
Hyperuricemia (HUA), a severe metabolic disease derived from purine metabolism disorder, will lead to abnormally increased serum uric acid (SUA) levels in the body. Studies have shown that HUA is highly related to gout, hypertension, diabetes, coronary heart disease, chronic kidney diseases, and so on. Traditional Chinese medicine (TCM) shows excellent results in treating HUA because of its unique advantages of multi-metabolites and multi-targets. This article reports on the use of TCM components for uric acid (UA)-lowering activity with excellent efficacy and low side effects based on established HUA models. This work summarizes the advantages and limitations of various HUA disease models for efficacy evaluation. Applications of TCM in HUA treatment have also been discussed in detail. This paper reveals recent research progress on HUA in constructing evaluation models and systematic TCM interventions. It will provide a scientific reference for establishing the HUA model and suggest future TCM-related HUA studies.
高尿酸血症（HUA）是一种由嘌呤代谢紊乱引起的严重代谢性疾病，会导致体内血清尿酸（SUA）水平异常升高。研究表明，HUA与痛风、高血压、糖尿病、冠心病、慢性肾脏疾病等密切相关。由于其多代谢产物和多靶点的独特优势，中药（TCM）在治疗HUA方面显示出优异的效果。本文报道了基于已建立的HUA模型，使用中药成分降低尿酸（UA）活性，疗效优异且副作用小。这项工作总结了各种用于疗效评估的HUA疾病模型的优缺点。还详细讨论了中药在HUA治疗中的应用。本文揭示了在构建评估模型和系统性中药干预方面HUA的最新研究进展。它将为建立HUA模型提供科学参考，并为未来与中药相关的HUA研究提供建议。
