Dabravolski Siarhei A, Churov Alexey V, Sukhorukov Vasily N, Kovyanova Tatiana I, Beloyartsev Dmitry F, Lyapina Irina N, Orekhov Alexander N
Department of Biotechnology Engineering, Braude Academic College of Engineering, Karmiel, Israel.
Institute of General Pathology and Pathophysiology, Moscow, Russia.
SAGE Open Med. 2024 Oct 16;12:20503121241289828. doi: 10.1177/20503121241289828. eCollection 2024.
Lipase maturation factor 1 is an endoplasmic reticulum-resident transmembrane protein, which acts as a critical chaperone necessary for the folding, dimerisation, and secretion of lipases. In this review, we summarise data about the recently revealed role of lipase maturation factor 1 in endoplasmic reticulum redox homeostasis, its novel interaction partners among oxidoreductases and lectin chaperones, and the identification of fibronectin and the low-density lipoprotein receptor as novel non-lipase client proteins of lipase maturation factor 1. Additionally, the role of lipase maturation factor 1-derived circular RNA in atherosclerosis progression via the miR-125a-3p/vascular endothelial growth factor A\Fibroblast Growth Factor 1 axis is discussed. Finally, we focus on the causative role of lipase maturation factor 1 variants in the development of hypertriglyceridaemia - a type of dyslipidaemia that significantly contributes to the development of atherosclerosis and other cardiovascular diseases via different mechanisms.
脂肪酶成熟因子1是一种驻留在内质网的跨膜蛋白，它作为一种关键的分子伴侣，对脂肪酶的折叠、二聚化和分泌是必需的。在这篇综述中，我们总结了有关脂肪酶成熟因子1在内质网氧化还原稳态中最近揭示的作用的数据，其在氧化还原酶和凝集素分子伴侣中的新型相互作用伙伴，以及纤连蛋白和低密度脂蛋白受体作为脂肪酶成熟因子1的新型非脂肪酶客户蛋白的鉴定。此外，还讨论了脂肪酶成熟因子1衍生的环状RNA通过miR-125a-3p/血管内皮生长因子A/成纤维细胞生长因子1轴在动脉粥样硬化进展中的作用。最后，我们聚焦于脂肪酶成熟因子1变体在高甘油三酯血症发生中的致病作用，高甘油三酯血症是一种血脂异常，通过不同机制显著促进动脉粥样硬化和其他心血管疾病的发展。
