Li Zonghuai, Li Anxia, Liu Pingping, Zhang Bo, Yan Yuanyuan
Scientific Research Center, Guilin Medical University, Guilin, China.
Department of Pharmacy, Sanya Central Hospital (The Third People's Hospital of Hainan Province), Sanya, Hainan, China.
Front Nutr. 2024 Oct 15;11:1485642. doi: 10.3389/fnut.2024.1485642. eCollection 2024.
The ketogenic diet (KD) has been explored for diabetes management; however, a quantitative synthesis of its specific effects on diabetes has not yet been conducted. This study aims to examine the current status and research hotspots of KD in diabetes management from 2005 to 2024, providing a reference for future research.
We retrieved articles published between 2005 and 2024 from the Web of Science database and analyzed them using R software, VOSviewer, and CiteSpace.
This study includes 432 relevant publications. From 2005 to 2024, the volume of literature in this field has shown a steady upward trend, with a notable increase from 2017 to 2021, and a slight decline observed from 2021 to 2023. The United States is the leading country in terms of the number of publications, followed by China, Australia, and Canada. The United States not only leads in publication volume but also maintains a broader international collaboration network. and the are the most frequently published and cited journals. Current research hotspots primarily focus on the impact of KD on blood glucose control, insulin resistance, and lipid metabolism in diabetic patients. Mechanistic studies on KD in diabetes management concentrate on aspects such as the "regulation of genes by β-hydroxybutyrate," "anti-inflammatory effects," and "oxidative stress." The role of the gut microbiome is also emerging as an important research area. Currently, exploring the application of KD in managing different age groups and types of diabetes has become a significant research trend.
As an emerging dietary intervention, KD is gradually attracting widespread attention from researchers around the world and is expected to become a major research focus in the future for diabetes management and control. This paper provides a systematic review and analysis of the current research status and hotspots of KD in diabetes management, offering important references and insights for future research in related fields.
生酮饮食（KD）已被用于糖尿病管理的探索；然而，尚未对其对糖尿病的具体影响进行定量综合分析。本研究旨在考察2005年至2024年KD在糖尿病管理中的现状和研究热点，为未来研究提供参考。
我们从科学网数据库中检索了2005年至2024年发表的文章，并使用R软件、VOSviewer和CiteSpace对其进行分析。
本研究纳入432篇相关出版物。2005年至2024年，该领域的文献数量呈稳步上升趋势，2017年至2021年显著增加，2021年至2023年略有下降。美国是发表文章数量最多的国家，其次是中国、澳大利亚和加拿大。美国不仅在发表量上领先，还保持着更广泛的国际合作网络。《 》和《 》是发表和被引用最频繁的期刊。当前的研究热点主要集中在KD对糖尿病患者血糖控制、胰岛素抵抗和脂质代谢的影响。KD在糖尿病管理中的机制研究集中在“β-羟基丁酸对基因的调控”、“抗炎作用”和“氧化应激”等方面。肠道微生物群的作用也正在成为一个重要的研究领域。目前，探索KD在不同年龄组和糖尿病类型管理中的应用已成为一个重要的研究趋势。
作为一种新兴的饮食干预措施，KD正逐渐受到全球研究人员的广泛关注，有望成为未来糖尿病管理和控制的主要研究重点。本文对KD在糖尿病管理中的当前研究现状和热点进行了系统综述和分析，为相关领域的未来研究提供了重要参考和见解。
