肿瘤治疗电场：胶质母细胞瘤患者的一种新治疗选择。
Tumor treating induced fields: a new treatment option for patients with glioblastoma.
作者信息
Cai Zehao, Yang Zukai, Wang Ying, Li Ye, Zhao Hong, Zhao Hanwen, Yang Xue, Wang Can, Meng Tengteng, Tong Xiao, Zheng Hao, He Zhaoyong, Niu Chunli, Yang Junzhi, Chen Feng, Yang Zhi, Zou Zhige, Li Wenbin
机构信息
Department of Neuro-oncology Cancer Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
School of Basic Medical Science, Capital Medical University, Beijing, China.
出版信息
Front Neurol. 2024 Oct 17;15:1413236. doi: 10.3389/fneur.2024.1413236. eCollection 2024.
PURPOSE
Currently, a range of electromagnetic therapies, including magnetic field therapy, micro-currents therapy, and tumor treating fields, are under investigation for their potential in central nervous system tumor research. Each of these electromagnetic therapies possesses distinct effects and limitations. Our focus is on overcoming these limitations by developing a novel electric field generator. This generator operates by producing alternating induced currents within the tumor area through electromagnetic induction.
METHODS
Finite element analysis was employed to calculate the distribution of electric fields. Cell viability was assessed using the CCK-8 assay. Tumor volumes and weights served as indicators to evaluate the effectiveness of TTIF. The imaging system was utilized to confirm tumor growth in the brains of mice.
RESULTS
TTIF significantly inhibited the proliferation of U87 cells both and .
CONCLUSION
TTIF significantly inhibited the proliferation of U87 cells both and . Consequently, TTIF emerges as a potential treatment option for patients with progressive or metastatic GBM.
目的
目前，一系列电磁疗法，包括磁场疗法、微电流疗法和肿瘤治疗电场，正在中枢神经系统肿瘤研究中探究其潜力。这些电磁疗法中的每一种都有独特的作用和局限性。我们的重点是通过开发一种新型电场发生器来克服这些局限性。该发生器通过电磁感应在肿瘤区域产生交变感应电流来运行。
方法
采用有限元分析来计算电场分布。使用CCK-8测定法评估细胞活力。肿瘤体积和重量作为评估TTIF有效性的指标。利用成像系统确认小鼠脑中肿瘤的生长情况。
结果
TTIF在……（此处原文缺失具体内容）均显著抑制U87细胞的增殖。
结论
TTIF在……（此处原文缺失具体内容）均显著抑制U87细胞的增殖。因此，TTIF成为进行性或转移性胶质母细胞瘤患者的一种潜在治疗选择。
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