中药联合阿奇霉素序贯疗法治疗儿童肺炎的疗效与安全性：一项随机对照试验的Meta分析
Efficacy and safety of traditional Chinese medicine combined with azithromycin sequential therapy for pneumonia among children: a meta-analysis of randomized controlled trials.
作者信息
Lyu Jing, Fan Fei, Li Ji, Wang Qiong, Tian Xue, Xu Jiaxing, Zhang Si, Wang Bo
机构信息
Department of Paediatrics, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
出版信息
Front Pharmacol. 2024 Oct 17;15:1431706. doi: 10.3389/fphar.2024.1431706. eCollection 2024.
BACKGROUND
Traditional Chinese medicine (TCM) is used to treat pneumonia (MP) in children with favorable treatment outcome in China. In the present study, we evaluated the clinical efficacy of TCM combined with azithromycin (AZM) for the treatment of MP among children, providing high evidence-based reference for clinical treatment.
METHOD
We retrieved eligible randomized controlled trials (RCTs) from CQVIP, CNKI, WanFang, NSTL, PubMed, Embase, and Embase databases from January 2000 to November 2023. Data extraction and quality assessment of the enrolled studies were independently by two reviewers. Review Manager 5.3 was used for meta-analysis.
RESULT
A total of 51 RCTs involving 5,799 children aged 1-14 enrolled. Meta-analysis demonstrated that TCM combined with AZM improved the cure rate (odds ratio [OR] = 2.34, 95% CI: 2.06 to 2.64) and the effective rate (OR = 5.21, 95% CI: 4.22 to 6.43), shorted the disappearance duration of cough (WMD = -1.62, 95% CI: -1.90 to -1.34), the duration of fever (WMD = -1.62, 95% CI: -1.96 to -1.29), and the disappearance time of lung rales (WMD = -1.15, 95% CI: -1.32 to -0.98), improved CRP levels (WMD = -2.06, 95% CI: -2.57 to -1.55), IL-6 levels (WMD = -1.92,95% CI: -2.51 to -1.34), and TNF-α levels (WMD = -1.59, 95% CI: -2.14 to -1.04), and reduced adverse reactions (OR = 0.37, 95% CI: 0.32 to 0.44).
CONCLUSION
TCM combined with AZM in the treatment of MP among children has favorable clinical efficacy and safety.
背景
在中国，中医用于治疗儿童支原体肺炎（MP），治疗效果良好。在本研究中，我们评估了中医联合阿奇霉素（AZM）治疗儿童MP的临床疗效，为临床治疗提供了高循证依据的参考。
方法
我们检索了2000年1月至2023年11月期间来自CQVIP、CNKI、万方、NSTL、PubMed、Embase和Embase数据库的符合条件的随机对照试验（RCT）。两名评审员独立进行纳入研究的数据提取和质量评估。使用Review Manager 5.3进行荟萃分析。
结果
共纳入51项RCT，涉及5799名1-14岁儿童。荟萃分析表明，中医联合AZM提高了治愈率（比值比[OR]=2.34，95%可信区间：2.06至2.64）和有效率（OR=5.21，95%可信区间：4.22至6.43），缩短了咳嗽消失时间（加权均数差[WMD]=-1.62，95%可信区间：-1.90至-1.34）、发热持续时间（WMD=-1.62，95%可信区间：-1.96至-1.29）和肺部啰音消失时间（WMD=-1.15，95%可信区间：-1.32至-0.98），改善了CRP水平（WMD=-2.06，95%可信区间：-2.57至-1.55）、IL-6水平（WMD=-1.92，95%可信区间：-2.51至-1.34）和TNF-α水平（WMD=-1.59，95%可信区间：-2.14至-1.04），并减少了不良反应（OR=0.37，95%可信区间：0.32至0.44）。
结论
中医联合AZM治疗儿童MP具有良好的临床疗效和安全性。
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