Department of Medicine, Nazarbayev University School of Medicine (Nur-Sultan), Nur-Sultan, Kazakhstan.
Clinical Academic Department of Pediatrics, National Research Center of Mother and Child Health, University Medical Center, Nur-Sultan, Kazakhstan.
Int J Clin Pract. 2022 Jul 8;2022:6343818. doi: 10.1155/2022/6343818. eCollection 2022.
(. ) is one of the leading causes of community-acquired pneumonia in children and is also implicated in a variety of reactive extrapulmonary diseases. Recurrent and/or severe respiratory infections are one of the most frequent manifestations of several types of primary immunodeficiency. Here, we reviewed the medical literature to assess the potential relevance of . in the infections observed in children affected with combined, humoral, and innate primary immune deficiencies. . does not result to be epidemiologically prevalent as a cause of pneumonia in children affected by primary immunodeficiencies, but this infection can have a persistent or severe course in this category of patients. Indeed, the active search of . could be useful and appropriate especially in children with humoral immune deficiencies. Indeed, most cases of . infection in primary immunodeficiencies are described in patients affected by a/hypo-gammaglobulinemia.
（肺炎支原体）是儿童社区获得性肺炎的主要病因之一，也与多种反应性肺外疾病有关。复发性和/或严重的呼吸道感染是几种原发性免疫缺陷的最常见表现之一。在这里，我们复习了医学文献，以评估肺炎支原体在合并性、体液性和先天性原发性免疫缺陷儿童中观察到的感染中的潜在相关性。肺炎支原体在患有原发性免疫缺陷的儿童肺炎病因中并不具有流行病学普遍性，但这种感染在这类患者中可能具有持续或严重的病程。事实上，积极寻找肺炎支原体是有用且合适的，特别是在患有体液免疫缺陷的儿童中。事实上，在原发性免疫缺陷患者中，大多数肺炎支原体感染病例都发生在低/无γ球蛋白血症患者中。
