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用动态模式对脑类器官进行神经刺激:一种针对再生神经医学的情感组学方法。

Neural Stimulation of Brain Organoids with Dynamic Patterns: A Sentiomics Approach Directed to Regenerative Neuromedicine.

作者信息

Pereira Alfredo, Garcia José Wagner, Muotri Alysson

机构信息

Philosophy Graduate Program, UNESP/Marilia Campus, São Paulo State University, Botucatu 18618-689, Brazil.

Architecture and Urbanism, USP and PUC, São Paulo, Brazil.

出版信息

NeuroSci. 2023 Jan 16;4(1):31-42. doi: 10.3390/neurosci4010004. eCollection 2023 Mar.

Abstract

The new science called aims to identify the dynamic patterns that endow living systems with the capacity to feel and become conscious. One of the most promising fields of investigation in is the development and 'education' of human brain organoids to become sentient and useful for the promotion of human health in the (also new) field of Regenerative Neuromedicine. Here, we discuss the type of informational-rich input necessary to make a brain organoid sentient in experimental settings. Combining this research with the ecological preoccupation of preserving ways of sentience in the Amazon Rainforest, we also envisage the development of a new generation of biosensors to capture dynamic patterns from the forest, and use them in the 'education' of brain organoids to afford them a 'mental health' quality that is likely to be important in future advances in 'post-humanist' procedures in regenerative medicine. This study is closely related to the psychophysical approach to human mental health therapy, in which we have proposed the use of dynamic patterns in electric and magnetic brain stimulation protocols, addressing electrochemical waves in neuro-astroglial networks.

摘要

一门名为[具体名称未给出]的新科学旨在识别赋予生命系统感知和意识能力的动态模式。[具体领域未明确]中最具前景的研究领域之一是人类脑类器官的发育和“培育”,使其具有感知能力,并在再生神经医学(也是一个新领域)中对促进人类健康发挥作用。在此,我们讨论在实验环境中使脑类器官具有感知能力所需的丰富信息输入类型。将这项研究与保护亚马逊雨林中感知方式的生态关注点相结合,我们还设想开发新一代生物传感器,以捕捉来自森林的动态模式,并将其用于脑类器官的“培育”,赋予它们一种“心理健康”特质,这在再生医学“后人文主义”程序的未来进展中可能至关重要。这项研究与人类心理健康治疗的心理物理学方法密切相关,在该方法中,我们提议在脑电和磁刺激方案中使用动态模式,以处理神经 - 星形胶质细胞网络中的电化学波。

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