Bodel P T, Major P T, Gee J B
Yale J Biol Med. 1979 May-Jun;52(3):247-56.
Blood monocytes from patients with sarcoidosis were incubated in vitro, and secretion of endogenous pyrogen (EP), the protein which mediates fever, and lysozyme (L) were measured. After incubation with endotoxin, monocytes from 5 patients with sarcoidosis released twice as much EP as did monocytes from normal individuals (p < .001). Initial 24-hr secretion of L by monocytes from 6 of 11 additional patients with sarcoidosis exceeded the normal range of values for cells from 11 age- and sex-matched control individuals. Cells with initially augmented secretion rates continued to secrete increased amounts of L for 3 days. A correlation was noted between in vitro secretion of L by monocytes and serum levels of L in the same patient. These studies indicate that circulating mononuclear cells in some patients with sarcoidosis have an increased capacity to secrete EP and/or L prior to tissue localization.
对结节病患者的血液单核细胞进行体外培养，并检测内源性致热原（EP，介导发热的蛋白质）和溶菌酶（L）的分泌情况。在用内毒素孵育后，5例结节病患者的单核细胞释放的EP量是正常个体单核细胞的两倍（p < 0.001）。另外11例结节病患者中有6例的单核细胞最初24小时的L分泌量超过了11名年龄和性别匹配的对照个体细胞的正常范围值。最初分泌率增加的细胞在3天内持续分泌更多的L。在同一患者中，单核细胞体外分泌L与血清L水平之间存在相关性。这些研究表明，一些结节病患者的循环单核细胞在组织定位之前分泌EP和/或L的能力增强。
