城市安全网诊所人群中快速长效注射暴露前预防实施的高留存率和依从性
High Retention and Adherence With Rapid Long-acting Injectable Preexposure Prophylaxis Implementation in an Urban Safety Net Clinic Population.
作者信息
Spinelli Matthew A, Bisom-Rapp Ezra, Heise Megan J, Camp Christina, Appa Ayesha, Liu Albert Y, Sassaman Kevin, Shiels Mary, Mayorga-Munoz Francis, Chimezie Anthonia, Nguyen Janet, Oskarsson Jon, Gandhi Monica
机构信息
Division of HIV, ID, and Global Medicine, University of California, San Francisco, California, USA.
Department of Medicine, University of California, San Francisco, California, USA.
出版信息
Clin Infect Dis. 2025 Jun 4;80(5):1139-1142. doi: 10.1093/cid/ciae531.
Abstract
In a low-barrier, long-acting preexposure prophylaxis (PrEP) program in a safety net setting, permitting same-day or next-day initiation, 85% of injections were on time, and 6-month retention was 83%, surpassing outcomes from most previously reported oral PrEP studies. With drop-in, wraparound services, similar retention among housing-insecure populations was seen. Long-acting PrEP expansion is urgently needed.
摘要
在安全网环境下实施的低障碍、长效暴露前预防（PrEP）项目中，允许当日或次日开始用药，85%的注射按时进行，6个月的留存率为83%，超过了此前大多数口服PrEP研究的结果。通过即到即服务和全面服务，在住房无保障人群中也观察到了类似的留存率。长效PrEP的推广迫在眉睫。
相似文献
1
High Retention and Adherence With Rapid Long-acting Injectable Preexposure Prophylaxis Implementation in an Urban Safety Net Clinic Population.城市安全网诊所人群中快速长效注射暴露前预防实施的高留存率和依从性
Clin Infect Dis. 2025 Jun 4;80(5):1139-1142. doi: 10.1093/cid/ciae531.
2
Awareness and intention to use event-driven and long-acting injectable pre-exposure prophylaxis among adolescent and young men who have sex with men and transgender women in Brazil: a cross-sectional study.巴西男男性行为者和跨性别女性中青少年对事件驱动型和长效注射用暴露前预防药物的知晓率及使用意愿：一项横断面研究
J Int AIDS Soc. 2025 Jul;28 Suppl 2(Suppl 2):e26479. doi: 10.1002/jia2.26479.
3
Efficacy and safety of long-acting cabotegravir compared with daily oral tenofovir disoproxil fumarate plus emtricitabine to prevent HIV infection in cisgender men and transgender women who have sex with men 1 year after study unblinding: a secondary analysis of the phase 2b and 3 HPTN 083 randomised controlled trial.长效卡替拉韦与每日口服替诺福韦酯富马酸二吡呋酯/恩曲他滨相比预防无对照研究 1 年后与男性发生性行为的顺性别男性和跨性别女性感染 HIV 的疗效和安全性：HPTN 083 随机对照 2b 期和 3 期试验的二次分析。
Lancet HIV. 2023 Dec;10(12):e767-e778. doi: 10.1016/S2352-3018(23)00261-8. Epub 2023 Nov 9.
4
PrEP15-19 Choices: an implementation study protocol of HIV prevention with oral and long-acting injectable cabotegravir PrEP in real-word settings among sexual and gender minority adolescents in Brazil.PrEP15 - 19选择：一项在巴西性少数和性别少数青少年的现实环境中使用口服和长效注射卡博特韦进行HIV预防的实施研究方案。
BMJ Open. 2025 Jan 20;15(1):e083146. doi: 10.1136/bmjopen-2023-083146.
5
Safety, tolerability, and acceptability of long-acting injectable cabotegravir for HIV prevention in cisgender female adolescents (HPTN 084-01): a single-arm, open-label, phase 2b trial.长效注射用卡博特韦用于顺性别女性青少年预防HIV的安全性、耐受性和可接受性（HPTN 084-01）：一项单臂、开放标签的2b期试验
Lancet HIV. 2025 Apr;12(4):e252-e260. doi: 10.1016/S2352-3018(24)00310-2. Epub 2025 Mar 12.
6
Location Preferences for Accessing Long-Acting Injectable Pre-Exposure Prophylaxis (LA-PrEP) Among Men Who Have Sex With Men (MSM) Currently on Daily Oral PrEP.目前正在每日口服暴露前预防药物（PrEP）的男男性行为者（MSM）中，获取长效注射用暴露前预防药物（LA-PrEP）的地点偏好。
J Int Assoc Provid AIDS Care. 2024 Jan-Dec;23:23259582241293336. doi: 10.1177/23259582241293336.
7
Preferences for on-demand/intermittent/event-driven and long-acting injectable (LAI) HIV pre-exposure prophylaxis (PrEP) among HIV-negative Black gay, bisexual, and other sexual minority men in the United States: A qualitative study.美国 HIV 阴性的黑人男同性恋者、双性恋者及其他性少数男性对按需/间歇性/事件驱动型和长效注射用艾滋病毒暴露前预防（PrEP）的偏好：一项定性研究。
PLoS One. 2025 Jun 30;20(6):e0323212. doi: 10.1371/journal.pone.0323212. eCollection 2025.
8
Exploring perceptions and preferences for PrEP choice and of an mHealth intervention: insights from the ImPrEP CAB-Brasil study.探索对暴露前预防（PrEP）选择及移动健康干预措施的认知和偏好：来自巴西ImPrEP社区咨询委员会（CAB）研究的见解
J Int AIDS Soc. 2025 Jul;28 Suppl 2(Suppl 2):e26493. doi: 10.1002/jia2.26493.
9
Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women.卡博特韦用于预防顺性别男性和跨性别女性中的 HIV。
N Engl J Med. 2021 Aug 12;385(7):595-608. doi: 10.1056/NEJMoa2101016.
10
Need for informed providers: exploring LA-PrEP access in focus groups with PrEP-indicated communities in Baltimore, Maryland.知情提供者的需求：在马里兰州巴尔的摩的有接受 PrEP 指征的社区的焦点小组中探索 LA-PrEP 的可及性。
BMC Public Health. 2024 May 8;24(1):1258. doi: 10.1186/s12889-024-18595-7.
引用本文的文献
1
Early Implementation of Long-Acting Injectable Cabotegravir for HIV Prevention in a Safety Net Hospital-based Primary Care Center in U.S. South.长效注射用卡博特韦在美国南部一家安全网医院初级保健中心用于预防HIV感染的早期实施情况。
J Gen Intern Med. 2025 Feb 11. doi: 10.1007/s11606-025-09350-8.
2
Why is roll-out of long-acting PrEP agents so slow?长效暴露前预防药物的推广为何如此缓慢？
Curr Opin HIV AIDS. 2025 Jan 1;20(1):48-53. doi: 10.1097/COH.0000000000000899. Epub 2024 Nov 14.
本文引用的文献
1
Feasibility of Implementing a Low-Barrier Long-Acting Injectable Antiretroviral Program for HIV Treatment and Prevention for People Experiencing Homelessness.在有 homelessness 经历的人群中实施一项低门槛长效注射型抗逆转录病毒治疗和预防计划的可行性。
J Acquir Immune Defic Syndr. 2024 May 1;96(1):61-67. doi: 10.1097/QAI.0000000000003396.
2
Efficacy and safety of long-acting cabotegravir compared with daily oral tenofovir disoproxil fumarate plus emtricitabine to prevent HIV infection in cisgender men and transgender women who have sex with men 1 year after study unblinding: a secondary analysis of the phase 2b and 3 HPTN 083 randomised controlled trial.长效卡替拉韦与每日口服替诺福韦酯富马酸二吡呋酯/恩曲他滨相比预防无对照研究 1 年后与男性发生性行为的顺性别男性和跨性别女性感染 HIV 的疗效和安全性：HPTN 083 随机对照 2b 期和 3 期试验的二次分析。
Lancet HIV. 2023 Dec;10(12):e767-e778. doi: 10.1016/S2352-3018(23)00261-8. Epub 2023 Nov 9.
3
Promises and challenges: cabotegravir for preexposure prophylaxis.优势与挑战：卡替拉韦用于暴露前预防。
Curr Opin HIV AIDS. 2022 Jul 1;17(4):186-191. doi: 10.1097/COH.0000000000000733. Epub 2022 Mar 4.
4
Projected Impact of Expanded Long-Acting Injectable PrEP Use Among Men Who Have Sex With Men on Local HIV Epidemics.扩大男男性行为人群长效注射型 HIV 预防用药的使用对当地 HIV 疫情的预估影响。
J Acquir Immune Defic Syndr. 2022 Oct 1;91(2):144-150. doi: 10.1097/QAI.0000000000003029.
5
Evaluation of the POP-UP programme: a multicomponent model of care for people living with HIV with homelessness or unstable housing.“弹出式”项目评估：针对无家可归或住房不稳定的艾滋病毒感染者的多成分照护模式
AIDS. 2021 Jul 1;35(8):1241-1246. doi: 10.1097/QAD.0000000000002843.
6
The Effect of Depression on Adherence to HIV Pre-exposure Prophylaxis Among High-Risk South African Women in HPTN 067/ADAPT.《在 HPTN 067/ADAPT 中，抑郁对南非高危女性人群中 HIV 暴露前预防用药依从性的影响》。
AIDS Behav. 2020 Jul;24(7):2178-2187. doi: 10.1007/s10461-020-02783-8.
7
Pre-exposure Prophylaxis Persistence Is a Critical Issue in PrEP Implementation.暴露前预防的持续性是暴露前预防实施中的一个关键问题。
Clin Infect Dis. 2020 Jul 27;71(3):583-585. doi: 10.1093/cid/ciz896.
8
Racial/ethnic and HIV risk category disparities in preexposure prophylaxis discontinuation among patients in publicly funded primary care clinics.在公共资金资助的初级保健诊所中，患者因种族/民族和 HIV 风险类别而中断暴露前预防的差异。
AIDS. 2019 Nov 15;33(14):2189-2195. doi: 10.1097/QAD.0000000000002347.
9
Interventions to Reduce Drug Use Among Methamphetamine Users at Risk for HIV.减少有感染 HIV 风险的甲基苯丙胺使用者药物使用的干预措施。
Curr HIV/AIDS Rep. 2019 Feb;16(1):29-36. doi: 10.1007/s11904-019-00423-y.
10
Brief Report: A Panel Management and Patient Navigation Intervention Is Associated With Earlier PrEP Initiation in a Safety-Net Primary Care Health System.简要报告：在一个医疗保障初级保健系统中，小组管理和患者导航干预与更早开始使用 PrEP 相关。
J Acquir Immune Defic Syndr. 2018 Nov 1;79(3):347-351. doi: 10.1097/QAI.0000000000001828.
Zotero 插件