大环配合物克服了血卟啉单甲醚的后处理光毒性。

A giant macrocycle overcomes the post-treatment phototoxicity of photofrin through host-guest complexation.

机构信息

State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China.

Academy of Interdisciplinary Studies on Intelligent Molecules, Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, P. R. China.

出版信息

Chem Commun (Camb). 2024 Nov 19;60(93):13686-13689. doi: 10.1039/d4cc04777j.

DOI:10.1039/d4cc04777j

PMID:39485031

Abstract

Here we reported a supramolecular sequestration strategy to overcome the post-treatment phototoxicity of photofrin direct host-guest complexation. Efficient recognition potency of a giant pentaphen[3]arene derivative could favor suppressing sunlight-induced skin damage through weakening the ability of complexed photofrin to generate singlet oxygen.

摘要

在这里，我们报道了一种超分子封闭策略，以克服血卟啉直接主客体络合的治疗后光毒性。超分子主体大环五苯[3]芳烃衍生物的有效识别能力可以通过削弱络合血卟啉生成单线态氧的能力，有利于抑制阳光引起的皮肤损伤。