通过全面绘制肿瘤动态发生图谱进行早期癌症检测。

Early Cancer Detection Through Comprehensive Mapping of Dynamic Tumorigenesis.

机构信息

Key Laboratory for Environment and Health, Department of Health Toxicology, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Key Laboratories of Molecular Oncology of Heilongjiang Province, Harbin, China.

出版信息

Cancer Discov. 2024 Nov 1;14(11):2037-2040. doi: 10.1158/2159-8290.CD-24-0831.

DOI:10.1158/2159-8290.CD-24-0831

PMID:39485248

Abstract

Current strategies for early cancer detection and diagnosis need updating to achieve greater precision, necessitating the creation of a comprehensive evolutionary map of tumorigenesis. This requires establishing high-quality prospective cohorts, systematically collecting samples for integrated spatiotemporal multiomics analyses, and efficiently translating laboratory findings into clinical applications.

摘要

当前的癌症早期检测和诊断策略需要更新，以实现更高的精度，这就需要创建一个全面的肿瘤发生进化图谱。这需要建立高质量的前瞻性队列，系统地收集样本进行整合的时空多组学分析，并有效地将实验室发现转化为临床应用。