Catholic University of the Sacred Heart and Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy.
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland.
Cancer Discov. 2024 Nov 1;14(11):2018-2020. doi: 10.1158/2159-8290.CD-24-1153.
In this issue, four articles highlight the critical role of nongenetic mechanisms and cell plasticity in mediating resistance to different classes of RAS inhibitors in pancreatic ductal adenocarcinoma and non-small cell lung cancer. See related article by Benitz et al., p. 2162 See related article by Dilly et al., p. 2135 See related article by Araujo et al., p. 2183 See related article by Singhal et al., p. 2122.
本期有四篇文章重点阐述了非遗传机制和细胞可塑性在介导胰腺导管腺癌和非小细胞肺癌对不同类别的 RAS 抑制剂的耐药性方面的关键作用。详见 Benitz 等人的相关文章，第 2162 页；Dilly 等人的相关文章，第 2135 页；Araujo 等人的相关文章，第 2183 页；以及 Singhal 等人的相关文章，第 2122 页。
