Hou Jingxin, Hu Cong, Li Hanyin, Liu Hongmei, Xiang Yangjiayi, Wu Gou, Li Yan
Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center & Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University, Shanghai 201203, China.
Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center & Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University, Shanghai 201203, China; Department of Pharmacy, Jing'an District Central Hospital of Shanghai, Jing'an Branch, the Affiliated Huashan Hospital of Fudan University, Shanghai 200040, China.
J Pharm Biomed Anal. 2025 Jan 15;253:116543. doi: 10.1016/j.jpba.2024.116543. Epub 2024 Oct 28.
Magnetic solid-phase extraction (MSPE) holds significant scientific and technological interest as a novel sample preparation method for complex samples due to its easy operation, swift separation, high adsorption efficiency, and environmental friendliness. As the core of MSPE, magnetic sorbents have captured tremendous attention in recent years. Various promising nanomaterials, such as metal-organic frameworks and covalent organic frameworks, have been synthesized and utilized as sorbents in pharmaceutical and biomedical analysis. This review intends to (1) summarize recent progress of magnetic sorbents applied in this area and discuss their advantages, disadvantages, possible interaction mechanisms with the target substances; (2) explore their innovative applications in the analysis of pharmaceuticals, proteins, peptides, nucleic acids, nucleosides, metabolites, and other disease biomarkers from 2021 to 2024; (3) present the integration of MSPE with emerging analytical technologies; and (4) discuss the current challenges and future perspectives. It is expected to provide references and insights for the development of novel magnetic sorbents and their applications in bioanalysis.
磁性固相萃取（MSPE）作为一种用于复杂样品的新型样品制备方法，因其操作简便、分离迅速、吸附效率高且环境友好而具有重大的科技意义。作为MSPE的核心，磁性吸附剂近年来受到了极大的关注。各种有前景的纳米材料，如金属有机框架和共价有机框架，已被合成并用作药物和生物医学分析中的吸附剂。本综述旨在：（1）总结磁性吸附剂在该领域的最新进展，并讨论其优缺点、与目标物质可能的相互作用机制；（2）探索它们在2021年至2024年期间在药物、蛋白质、肽、核酸、核苷、代谢物及其他疾病生物标志物分析中的创新应用；（3）介绍MSPE与新兴分析技术的整合；（4）讨论当前面临的挑战和未来展望。期望能为新型磁性吸附剂的开发及其在生物分析中的应用提供参考和见解。
