Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Institute for Engineering in Medicine, Health & Human Performance (EnMed), Batten College of Engineering and Technology, Old Dominion University, Norfolk, VA 23529, USA.
Int J Pharm. 2024 Dec 25;667(Pt A):124847. doi: 10.1016/j.ijpharm.2024.124847. Epub 2024 Oct 30.
Cancer continues to pose a formidable threat, claiming millions of lives annually. A beacon of hope in this battle lies in the realm of bioactive glasses, which have undergone a remarkable evolution over the past five decades. Among these, mesoporous bioactive glasses (MBGs) emerge as a dynamic subset endowed with customizable attributes such as high surface area and porosity. While holding immense promise for cancer care, the full clinical potential of MBGs remains largely unexplored. This review delves into the cutting-edge advancements in MBG technology, illuminating their pivotal role in cancer management - spanning from early detection to targeted therapeutic interventions like photothermal and photodynamic treatments. Furthermore, the molecular mechanisms underpinning MBGs' anticancer properties are elucidated, alongside an exploration of existing limitations in their application. Through this comprehensive synthesis, the significance of MBGs in revolutionizing cancer therapy is underscored, underscoring the urgent need for continued research to unlock their full potential in reshaping the landscape of cancer care.
癌症仍然构成巨大威胁，每年导致数百万人死亡。在这场战斗中，希望的灯塔在于生物活性玻璃领域，它在过去五十年中经历了显著的发展。其中，介孔生物活性玻璃（MBG）作为一个充满活力的子集脱颖而出，具有可定制的特性，如高表面积和孔隙率。尽管在癌症治疗方面具有巨大的潜力，但 MBG 的全部临床潜力在很大程度上仍未得到探索。这篇综述深入探讨了 MBG 技术的最新进展，阐明了它们在癌症管理中的关键作用——从早期检测到光热和光动力治疗等靶向治疗干预。此外，还阐明了 MBG 抗癌特性的分子机制，并探讨了其应用中存在的现有局限性。通过这种综合分析，强调了 MBG 在癌症治疗领域的重要性，突显了继续研究以释放其潜力、重塑癌症治疗领域的迫切需要。
