Trauma Medicine Center, Peking University People's Hospital, Beijing, China; Key Laboratory of Trauma and Neural Regeneration, Ministry of Education, Peking University, Beijing, China; National Center for Trauma Medicine, Beijing, China.
Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine, Guangxi, China.
Carbohydr Polym. 2025 Jan 1;347:122731. doi: 10.1016/j.carbpol.2024.122731. Epub 2024 Sep 11.
Chronic wound treatment has always been a major clinical challenge owing to complex and dynamic wound microenvironment. The design and development of effective management with antimicrobial activity, ROS-scavenging and regulation immune response is vital for tissue repair. Herein, we developed puerarin (PUE) loaded a double network hydrogel consisting of methacrylated carboxymethyl chitosan and oxidized dextran with Schiff base and photo-crosslinking reaction. The composite hydrogel presented fast self-healing and outstanding compressive performance to bear deformation. The hydrogel exhibits a cumulative drug release pattern with biphasic release, which offers great potential for accelerating tissue healing at all stages of wounding. In addition, the hydrogel has good biocompatibility, antimicrobial ability and tube-forming ability in vitro. The full-thickness skin wound model of Staphylococcus aureus infection showed that the hydrogel dressing can accelerate tissue repair. This study demonstrated that the design of combing natural biomacromolecules with traditional Chinese medicine could be severed as a promising candidate biomaterial for skin tissue recovery.
慢性创面治疗一直是一个重大的临床挑战，因为创面微环境复杂且动态变化。具有抗菌活性、ROS 清除和调节免疫反应的有效管理的设计和开发对于组织修复至关重要。在此，我们开发了葛根素（PUE）负载双网络水凝胶，该水凝胶由甲基丙烯酰化羧甲基壳聚糖和氧化葡聚糖通过席夫碱和光交联反应组成。该复合水凝胶具有快速自修复和出色的压缩性能，可承受变形。水凝胶表现出具有两相释放的累积药物释放模式，这为加速创面各个阶段的组织愈合提供了巨大的潜力。此外，水凝胶在体外具有良好的生物相容性、抗菌能力和管状形成能力。金黄色葡萄球菌感染的全厚皮肤创面模型表明，水凝胶敷料可以加速组织修复。本研究表明，将天然生物大分子与中药相结合的设计可以作为一种有前途的皮肤组织修复生物材料。
