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用于伤口愈合的负载草药生物活性成分的生物聚合物制剂。

Herbal bioactive-loaded biopolymeric formulations for wound healing applications.

作者信息

Jangra Nitin, Singla Aakanksha, Puri Vivek, Dheer Divya, Chopra Hitesh, Malik Tabarak, Sharma Ameya

机构信息

Chitkara University School of Pharmacy, Chitkara University Baddi 174103 Himachal Pradesh India

Department of Biosciences, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences Chennai - 602105 Tamil Nadu India.

出版信息

RSC Adv. 2025 Apr 17;15(16):12402-12442. doi: 10.1039/d4ra08604j. eCollection 2025 Apr 16.

Abstract

Recent advancements in wound healing technologies focus on incorporating herbal bioactives into biopolymeric formulations. A biocompatible matrix that promotes healing is provided by biopolymeric wound dressings. These dressings use components such as ulvan, hyaluronic acid, starch, cellulose, chitosan, alginate, gelatin, and pectin. These natural polymers assist in three crucial processes, namely, cell adhesion, proliferation, and moisture retention, all of which are necessary for effective wound repair. Curcumin, quercetin, , alkaloids, and are some of the herbal bioactives that are included in biopolymeric formulations. They have powerful anti-inflammatory, antibacterial, and antioxidant activities. Chitosan, cellulose, collagen, alginate, and hyaluronic acid are some of the biopolymers that have shown promise in clinical trials for wound healing. These trials have also confirmed the safety and functional performance of these materials. Their recent advancements in wound care can be understood by the increasing number of patents linked to these formulations. These innovative dressings improve healing outcomes in acute and chronic wounds while minimizing adverse effects by incorporating biopolymers with herbal bioactives in an efficient manner. This review emphasizes that the development of next-generation wound care products can be facilitated the integration of natural materials and bioactive substances.

摘要

伤口愈合技术的最新进展集中在将草药生物活性成分纳入生物聚合物配方中。生物聚合物伤口敷料提供了一种促进愈合的生物相容性基质。这些敷料使用诸如岩藻依聚糖、透明质酸、淀粉、纤维素、壳聚糖、藻酸盐、明胶和果胶等成分。这些天然聚合物有助于三个关键过程,即细胞粘附、增殖和保湿,所有这些都是有效伤口修复所必需的。姜黄素、槲皮素、生物碱等是生物聚合物配方中包含的一些草药生物活性成分。它们具有强大的抗炎、抗菌和抗氧化活性。壳聚糖、纤维素、胶原蛋白、藻酸盐和透明质酸是一些在伤口愈合临床试验中显示出前景的生物聚合物。这些试验也证实了这些材料的安全性和功能性能。通过与这些配方相关的专利数量不断增加,可以了解它们在伤口护理方面的最新进展。这些创新敷料通过以有效方式将生物聚合物与草药生物活性成分结合,改善了急性和慢性伤口的愈合效果,同时将不良反应降至最低。这篇综述强调,天然材料和生物活性物质的整合可以促进下一代伤口护理产品的开发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74c5/12005159/ef217dc4a725/d4ra08604j-f1.jpg

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