Engineering Research Center of Knitting Technology, Ministry of Education, College of Textile Science and Engineering, Jiangnan University, Wuxi 214122, China.
State Key Laboratory of New Textile Materials and Advanced Processing Technologies and National Local Joint Laboratory for Advanced Textile Processing and Clean Production, Wuhan Textile University, Wuhan 430200, China.
Carbohydr Polym. 2025 Jan 1;347:122761. doi: 10.1016/j.carbpol.2024.122761. Epub 2024 Sep 17.
Skin, as the biggest organ and outermost surface of the human body, is prone to injury due to various challenges, especially the expanding potential of accidents, which bring a huge social and economic burden. Hydrogels are emerging as the most promising candidate for wound dressings, which not only fulfill the varied requirements of dressings but also serve as drug carriers. But limited breathability, rapid drug release, and inadequate mechanical properties remains a significant challenge. Herein, we report a strong and tough sodium alginate/polyacrylate hydrogel fibers-based dressing with directional controlled drug release for wound healing promotion. Mimicking the bamboo structure, the drug solution is encapsulated within the fiber, and the rate of drug release can be modulated by controlling the wall thickness of the fiber. A cross-network structure in the hydrogel fiber through hydrogen bond and calcium ion crosslinking resulted in a 38 % increase in tensile strength. By precisely controlling the feeding process during weaving, drug-loaded fibers can be prepared at specific locations to facilitate targeted delivery to skin wound sites. Drug-loaded fabric has the breathability and biocompatibility required for dressings to promote wound healing. The findings highlight the potential of alginate/polyacrylate hydrogel fabrics for effective wound treatment.
皮肤作为人体最大的器官和最外层的表面，容易受到各种挑战的伤害，特别是事故的潜在扩张，这给社会和经济带来了巨大的负担。水凝胶作为伤口敷料最有前途的候选材料，不仅满足了敷料的各种要求，而且还可以作为药物载体。但是，透气性有限、药物释放迅速以及机械性能不足仍然是一个重大挑战。在此，我们报道了一种具有强韧的、基于海藻酸钠/聚丙烯酸水凝胶纤维的敷料，它具有定向控制药物释放的功能，可促进伤口愈合。模仿竹子的结构，将药物溶液包裹在纤维内，并通过控制纤维的壁厚来调节药物释放的速度。通过氢键和钙离子交联在水凝胶纤维中形成的交联网络结构，使拉伸强度提高了 38%。通过在编织过程中精确控制供料过程，可以在特定位置制备载药纤维，以方便将药物靶向递送到皮肤伤口部位。载药织物具有促进伤口愈合所需的透气性和生物相容性。这些发现突出了海藻酸钠/聚丙烯酸水凝胶织物在有效治疗伤口方面的潜力。
