School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China; National Engineering Lab of Textile Fiber Materials & Processing Technology, Hangzhou 310018, China.
National Engineering Lab of Textile Fiber Materials & Processing Technology, Hangzhou 310018, China.
Int J Biol Macromol. 2020 Aug 15;157:522-529. doi: 10.1016/j.ijbiomac.2020.04.210. Epub 2020 Apr 28.
In this work, alginate hydrogel fibers loading sulfanilamide were proposed using a combination of Ca ions and glutaraldehyde crosslinking to develop an efficient wound dressing. The structure, mechanical properties, absorbency, in vitro drug release and cytotoxicity of the proposed alginate hydrogel fibers were investigated systematically. The results indicated that crosslinking with glutaraldehyde can efficiently enhance the mechanical properties of the alginate hydrogel fibers, and reduce their swelling degree which is beneficial for hydrogel fibers to obtain adjustable fluid adsorption capacity, sustained drug release feature over hydrogel fibers crosslinked only by Ca ions. Antibacterial activity assay demonstrated the bactericidal ability of the alginate hydrogel fibers towards S. aureus and E. coli with the highest antibacterial rate of 99.9%. Furthermore, a preliminary trial of papermaking process for producing alginate hydrogel mats showed the workability and the applicability of the mechanically tough hydrogel fibers. Cytotoxicity assay indicated the enhancement of cell adhesion and proliferation, revealing the non-cytotoxicity and biocompatibility of the alginate hydrogel mats. Based on the excellent mechanical strength, adjustable fluid adsorption capacity, sustained drug release, and biocompatibility, the bi-crosslinked alginate hydrogel fibers had a promising application as ideal wound dressings in clinic.
在这项工作中，通过使用钙离子和戊二醛交联相结合的方法，提出了负载磺胺的海藻酸盐水凝胶纤维，以开发一种有效的伤口敷料。系统研究了所提出的海藻酸盐水凝胶纤维的结构、力学性能、吸液性、体外药物释放和细胞毒性。结果表明，戊二醛交联可以有效地提高海藻酸盐水凝胶纤维的力学性能，降低其溶胀度，有利于水凝胶纤维获得可调节的流体吸附能力和通过仅用钙离子交联的水凝胶纤维的持续药物释放特性。抗菌活性测定表明，海藻酸盐水凝胶纤维对金黄色葡萄球菌和大肠杆菌具有杀菌能力，最高杀菌率达到 99.9%。此外，用于制造海藻酸盐水凝胶垫的初步造纸工艺试验表明，机械强度高的水凝胶纤维具有可操作性和适用性。细胞毒性试验表明，细胞黏附和增殖得到增强，表明海藻酸盐水凝胶垫无细胞毒性和生物相容性。基于优异的力学强度、可调节的流体吸附能力、持续的药物释放和生物相容性，双交联海藻酸盐水凝胶纤维有望作为理想的临床伤口敷料得到应用。
