Nagel K, Ghussen F, Günther M
Dtsch Med Wochenschr. 1986 Feb 28;111(9):337-41. doi: 10.1055/s-2008-1068452.
Malignant melanoma of the anal canal in stages I, II and III, respectively, was diagnosed in a 58-year-old woman and two men, aged 69 and 73 years. The patients' age was thus above the average reported age of manifestation (60 years) of this tumour. In two patient the tumours had been incorrectly diagnosed because of their proximity to the linea dentata and their similarity to haemorrhoids: operation had been delayed for four and about six months, respectively. Treatment of choice for stages I and II was abdominoperineal amputation of the rectum, while in the patient with stage III a colostomy was performed as a local palliative measure. The patients with stage II and III tumour died after six and 12 months, respectively, a survival time which corresponds to that expected from published series. Radiotherapy did not influence tumour growth in the patient in stage III. The patient in stage I has been free of tumour for six months.
分别在一名58岁女性以及两名年龄为69岁和73岁的男性患者中诊断出I期、II期和III期肛管恶性黑色素瘤。这些患者的年龄高于该肿瘤报告的平均发病年龄(60岁)。在两名患者中,由于肿瘤靠近齿状线且与痔疮相似,导致诊断错误:手术分别推迟了四个月和大约六个月。I期和II期的首选治疗方法是直肠腹会阴切除术,而对于III期患者,则进行结肠造口术作为局部姑息措施。II期和III期肿瘤患者分别在6个月和12个月后死亡,其生存时间与已发表系列报道的预期相符。放疗对III期患者的肿瘤生长没有影响。I期患者已无瘤生存6个月。