新冠疫情期间阿尔茨海默病的死亡率
Mortality for Alzheimer's disease during the COVID-19 pandemic.
作者信息
Mattiuzzi Camilla, Lippi Giuseppe
机构信息
Medical Direction, Provincial Agency for Social and Sanitary Services (APSS), Rovereto Hospital, Trento, Italy.
Section of Clinical Biochemistry, University of Verona, Piazzale L.A. Scuro, 10, 37134, Verona, Italy.
出版信息
Eur Geriatr Med. 2025 Feb;16(1):379-381. doi: 10.1007/s41999-024-01096-6. Epub 2024 Nov 1.
AIM
Coronavirus disease 2019 (COVID-19) negatively impacts the progression of Alzheimer's disease. The aim of this study was to determine whether mortality from Alzheimer's disease has changed during the COVID-19 pandemic.
METHODS
We searched the WONDER database, to obtain cumulative and sex-specific age-adjusted death rates of Alzheimer's disease between the years 2018 and 2022.
RESULTS
Cumulative age-adjusted mortality rate displayed a peak in 2020, followed by gradual decline thereafter. The data for both sexes mirror that of total population, peaking in 2020, followed by a decline thereafter. The relative increase in age-adjusted mortality for Alzheimer's disease in 2020 compared to 2019 was + 8.7% in the total population, + 6.1% in men and + 10.1% in women.
CONCLUSIONS
Frail people, such as those with Alzheimer's disease, may be more vulnerable to the risk of dying during an outbreak of infectious disease, paving the way for increased preventive and protective measures in the unfortunate event of the next pandemic.
目的
2019年冠状病毒病（COVID-19）对阿尔茨海默病的进展产生负面影响。本研究的目的是确定在COVID-19大流行期间阿尔茨海默病的死亡率是否发生了变化。
方法
我们检索了WONDER数据库，以获取2018年至2022年期间阿尔茨海默病的累积及按性别和年龄调整的死亡率。
结果
累积年龄调整死亡率在2020年达到峰值，此后逐渐下降。两性的数据反映了总人口的情况，在2020年达到峰值，随后下降。与2019年相比，2020年阿尔茨海默病年龄调整死亡率的相对增幅在总人口中为+8.7%，男性为+6.1%，女性为+10.1%。
结论
体弱的人，如患有阿尔茨海默病的人，在传染病暴发期间可能更容易面临死亡风险，这为在下一次大流行的不幸情况下加强预防和保护措施铺平了道路。
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