眼睑非典型性和巨大性毛母质瘤：临床病理报告。
Atypical and giant proliferating pilomatrixoma of the eyelid: a clinicopathological report.
机构信息
Department of Oculo-Facial Plastic and Reconstructive Surgery, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pathology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
BMC Ophthalmol. 2024 Nov 1;24(1):477. doi: 10.1186/s12886-024-03748-4.
BACKGROUND
Pilomatrixoma is an uncommon benign skin neoplasm originating from the hair follicle. Here, we report a rare case of giant and atypical proliferating pilomatrixoma affecting the eyelid.
CASE PRESENTATION
A 47-year-old male presented with a solitary, giant mass on his left upper eyelid, which had recently shown progressive enlargement. The lesion appeared well-circumscribed with a firm consistency, and measuring 7 × 10 cm. Orbital computed tomography scan revealed no intraorbital extension. The lesion was surgically excised. Histopathological examination identified the mass as an atypical proliferating pilomatrixoma, characterized by a minimal infiltrating margin of the deep plane and focal cytological atypia of the basaloid cells. No recurrence was observed up to one year postoperatively.
CONCLUSIONS
Pilomatrixoma is a rare periocular tumor with potential for malignant transformation, often mimicking other lesions in this region. Therefore, any enlarging masses in this area should be excised for histopathological evaluation to rule out malignancy.
背景
毛发基质瘤是一种罕见的起源于毛囊的良性皮肤肿瘤。本文报告了一例罕见的发生于眼睑的巨大且非典型性增生性毛发基质瘤。
病例介绍
一名 47 岁男性因左上眼睑的孤立性巨大肿块就诊，该肿块近期逐渐增大。病变边界清楚，质地坚实，大小为 7×10cm。眼眶计算机断层扫描显示无眶内扩展。行手术切除。组织病理学检查提示为非典型性增生性毛发基质瘤，其特征为深部平面的最小浸润性边界和基底样细胞的局灶性细胞学异型性。术后 1 年未见复发。
结论
毛发基质瘤是一种罕见的眶周肿瘤，具有恶性转化的潜能，常与该区域的其他病变相混淆。因此，该区域任何增大的肿块均应切除进行组织病理学评估，以排除恶性肿瘤。
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