Ting Ke-Hsin, Yang Po-Jen, Tsai Po-Yu, Lee Chia-Yi, Yang Shun-Fa
Division of Cardiology, Department of Internal Medicine, Yunlin Branch, Changhua Christian Hospital, Yunlin, Taiwan.
Department of Nursing, Hungkuang University, Taichung, Taiwan.
Diabetol Metab Syndr. 2024 Nov 1;16(1):260. doi: 10.1186/s13098-024-01502-w.
Diabetic kidney disease (DKD) is a common complication of type 2 diabetes mellitus (T2DM) that leads to systemic inflammation. Maternally expressed gene 3 (MEG3) is a tumor suppressor that is involved in inflammation regulation. The current study investigated the association between DKD and the prevalence of the single-nucleotide polymorphisms (SNPs) of MEG3.
A total of 706 and 735 patients were included in the DKD and non-DKD groups, respectively. The five SNPs of MEG3, namely rs4081134 (G/A), rs10144253 (T/C), rs7158663 (G/A), rs3087918 (T/G), and rs11160608 (A/C), were genotyped using TaqMan allelic discrimination.
Our results revealed that, in the DKD group, the distribution of the GG genotype of the MEG3 SNP rs3087918 was significantly lower than that of the wild-type genotype (AOR: 0.703, 95% CI: 0.506-0.975, P = 0.035). In addition, in the pre-ESRD DKD subgroup, the distribution of the TG + GG genotype of the MEG3 SNP rs3087918 was significantly lower than that of the wild-type genotype (AOR: 0.637, 95% CI: 0.421-0.962, P = 0.032). In addition, among men in the DKD subgroup, the distribution of the GG genotype of the MEG3 SNP rs3087918 was significantly lower than that of the wild-type genotype (AOR: 0.630, 95% CI: 0.401-0.990, P = 0.045). Glycated hemoglobin (HbA1c) level was significantly higher in all T2DM patients with the wild-type genotype of the MEG3 SNP rs3087918 (P = 0.020). In addition, HbA1c levels were significantly higher in male patients and male DKD patients with the wild-type genotype of the MEG3 SNP rs3087918 (P = 0.032 and 0.031, respectively).
MEG3 SNP rs3087918 is significantly less prevalent in patients with DKD, and the SNP rs3087918 of MEG3 is associated with lower HbA1c levels.
糖尿病肾病（DKD）是2型糖尿病（T2DM）的常见并发症，可导致全身炎症。母系表达基因3（MEG3）是一种参与炎症调节的肿瘤抑制因子。本研究调查了DKD与MEG3单核苷酸多态性（SNP）患病率之间的关联。
DKD组和非DKD组分别纳入706例和735例患者。采用TaqMan等位基因分型法对MEG3的5个SNP，即rs4081134（G/A）、rs10144253（T/C）、rs7158663（G/A）、rs3087918（T/G）和rs11160608（A/C）进行基因分型。
我们的结果显示，在DKD组中，MEG3 SNP rs3087918的GG基因型分布显著低于野生型基因型（比值比：0.703，95%置信区间：0.506 - 0.975，P = 0.035）。此外，在终末期肾病前DKD亚组中，MEG3 SNP rs3087918的TG + GG基因型分布显著低于野生型基因型（比值比：0.637，95%置信区间：0.421 - 0.962，P = 0.032）。此外，在DKD亚组男性中，MEG3 SNP rs3087918的GG基因型分布显著低于野生型基因型（比值比：0.630，95%置信区间：0.401 - 0.990，P = 0.045）。MEG3 SNP rs3087918野生型基因型的所有T2DM患者糖化血红蛋白（HbA1c）水平显著更高（P = 0.020）。此外，MEG3 SNP rs3087918野生型基因型的男性患者和男性DKD患者HbA1c水平显著更高（分别为P = 0.032和0.031）。
MEG3 SNP rs3087918在DKD患者中的患病率显著较低，并与较低的HbA1c水平相关。
