• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Novel Contribution of Long Non-coding RNA Genotype to Prediction of Childhood Leukemia Risk.长链非编码 RNA 基因型对儿童白血病风险预测的新贡献
Cancer Genomics Proteomics. 2022 Jan-Feb;19(1):27-34. doi: 10.21873/cgp.20301.
2
Novel genetic variants in long non-coding RNA MEG3 are associated with the risk of asthma.长非编码 RNA MEG3 中的新型遗传变异与哮喘风险相关。
PeerJ. 2023 Jan 27;11:e14760. doi: 10.7717/peerj.14760. eCollection 2023.
3
The Genetic Variants of Long Noncoding RNA and Its Association to the Clinical Features of Diabetic Retinopathy.长链非编码 RNA 的遗传变异及其与糖尿病视网膜病变临床特征的关系。
Curr Eye Res. 2024 Sep;49(9):980-987. doi: 10.1080/02713683.2024.2350590. Epub 2024 May 8.
4
LncRNA MEG3 rs3087918 was associated with a decreased breast cancer risk in a Chinese population: a case-control study.长链非编码 RNA MEG3 rs3087918 与中国人群乳腺癌风险降低相关：一项病例对照研究。
BMC Cancer. 2020 Jul 15;20(1):659. doi: 10.1186/s12885-020-07145-0.
5
Association Between Long Noncoding RNA MEG3 Polymorphisms and Lung Cancer Susceptibility in Chinese Northeast Population.长链非编码 RNA MEG3 多态性与中国东北地区人群肺癌易感性的关联。
DNA Cell Biol. 2018 Oct;37(10):812-820. doi: 10.1089/dna.2018.4277. Epub 2018 Aug 16.
6
Association analyses of a genetic variant in long non-coding RNA MEG3 with breast cancer susceptibility and serum MEG3 expression level in the Egyptian population.长链非编码 RNA MEG3 中的遗传变异与乳腺癌易感性及埃及人群血清 MEG3 表达水平的关联分析。
Cancer Biomark. 2020;28(1):49-63. doi: 10.3233/CBM-191072.
7
Associations between lncRNA polymorphisms and neuroblastoma risk in Chinese children.中国儿童lncRNA多态性与神经母细胞瘤风险的关联。
Aging (Albany NY). 2018 Mar 27;10(3):481-491. doi: 10.18632/aging.101406.
8
Relationship between MEG3 gene polymorphism and risk of gastric cancer in Chinese population with high incidence of gastric cancer.MEG3 基因多态性与高发胃癌人群胃癌发病风险的关系。
Biosci Rep. 2020 Nov 27;40(11). doi: 10.1042/BSR20200305.
9
The emerging role of lncRNA MEG3 and MEG3 rs7158663 in hepatocellular carcinoma.长链非编码 RNA MEG3 及其 rs7158663 位点在肝细胞癌中的新兴作用。
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):11-21. doi: 10.26355/eurrev_202201_27742.
10
Association between MEG3/miR-181b polymorphisms and risk of ischemic stroke.MEG3/miR-181b 多态性与缺血性脑卒中风险的关联。
Lipids Health Dis. 2018 Dec 22;17(1):292. doi: 10.1186/s12944-018-0941-z.

引用本文的文献

1
Association of long noncoding RNA MEG3 genetic variants with the risk of diabetic neuropathy.长链非编码RNA MEG3基因变异与糖尿病性神经病变风险的关联
Int J Med Sci. 2025 Jul 10;22(13):3242-3249. doi: 10.7150/ijms.112883. eCollection 2025.
2
Aberrant Expression of Non-Coding RNAs in Pediatric T Acute Lymphoblastic Leukemia and Their Potential Application as Biomarkers.非编码RNA在儿童T细胞急性淋巴细胞白血病中的异常表达及其作为生物标志物的潜在应用
Genes (Basel). 2025 Mar 31;16(4):420. doi: 10.3390/genes16040420.
3
Impact of DNA Ligase 1 Genotypes on Childhood Acute Lymphocytic Leukemia.DNA连接酶1基因分型对儿童急性淋巴细胞白血病的影响
In Vivo. 2025 Jan-Feb;39(1):152-159. doi: 10.21873/invivo.13813.
4
Contribution of Cyclin Dependent Kinase Inhibitor 1A Genotypes to Childhood Acute Lymphocytic Leukemia Risk in Taiwan.细胞周期蛋白依赖性激酶抑制剂1A基因分型对台湾儿童急性淋巴细胞白血病风险的影响
Cancer Genomics Proteomics. 2025 Jan-Feb;22(1):46-54. doi: 10.21873/cgp.20486.
5
Neighborhood based computational approaches for the prediction of lncRNA-disease associations.基于社区的计算方法预测 lncRNA-疾病关联。
BMC Bioinformatics. 2024 May 13;25(1):187. doi: 10.1186/s12859-024-05777-8.
6
An Association Between GAS5 rs145204276, NEAT1 rs512715, and MEG3 rs4081134 Gene Polymorphisms and Papillary Thyroid Carcinoma.GAS5基因rs145204276、NEAT1基因rs512715和MEG3基因rs4081134多态性与甲状腺乳头状癌之间的关联。
Rep Biochem Mol Biol. 2023 Oct;12(3):487-494. doi: 10.61186/rbmb.12.3.487.
7
Non-homologous End-joining Genotype, mRNA Expression, and DNA Repair Capacity in Childhood Acute Lymphocytic Leukemia.儿童急性淋巴细胞白血病中的非同源末端连接基因型、mRNA 表达和 DNA 修复能力。
Cancer Genomics Proteomics. 2024 Mar-Apr;21(2):144-157. doi: 10.21873/cgp.20436.
8
Novel genetic variants in long non-coding RNA MEG3 are associated with the risk of asthma.长非编码 RNA MEG3 中的新型遗传变异与哮喘风险相关。
PeerJ. 2023 Jan 27;11:e14760. doi: 10.7717/peerj.14760. eCollection 2023.
9
Underexpression of in -Positive Cases Is Associated With Poor Prognosis in Children With B-Cell Precursor Acute Lymphoblastic Leukemia.在B细胞前体急性淋巴细胞白血病患儿中，阳性病例的低表达与预后不良相关。
Front Oncol. 2022 Jun 2;12:887766. doi: 10.3389/fonc.2022.887766. eCollection 2022.
10
Linear and Circular Long Non-Coding RNAs in Acute Lymphoblastic Leukemia: From Pathogenesis to Classification and Treatment.线性和环状长非编码 RNA 在急性淋巴细胞白血病中的作用：从发病机制到分类和治疗。
Int J Mol Sci. 2022 Apr 18;23(8):4442. doi: 10.3390/ijms23084442.

本文引用的文献

1
Significant Association of Genotypes With Susceptibility to Childhood Acute Lymphoblastic Leukemia.基因型与儿童急性淋巴细胞白血病易感性显著相关。
Anticancer Res. 2021 Oct;41(10):4801-4806. doi: 10.21873/anticanres.15295.
2
The Impact of Single Nucleotide Polymorphism in the Long Non-coding MEG3 Gene on MicroRNA-182 and MicroRNA-29 Expression Levels in the Development of Breast Cancer in Egyptian Women.单核苷酸多态性在长链非编码MEG3基因中对埃及女性乳腺癌发生发展过程中MicroRNA-182和MicroRNA-29表达水平的影响
Front Genet. 2021 Aug 4;12:683809. doi: 10.3389/fgene.2021.683809. eCollection 2021.
3
Significant Associations of lncRNA H19 Genotypes with Susceptibility to Childhood Leukemia in Taiwan.台湾lncRNA H19基因分型与儿童白血病易感性的显著关联
Pharmaceuticals (Basel). 2021 Mar 8;14(3):235. doi: 10.3390/ph14030235.
4
Association of Long Non-Coding RNA MEG3 Polymorphisms and Risk of Prostate Cancer in Chinese Han Population.长链非编码 RNA MEG3 多态性与中国汉族人群前列腺癌风险的关联。
Urol J. 2020 Aug 22;18(2):176-180. doi: 10.22037/uj.v16i7.5585.
5
MiR-196a-2 Genotypes Determine the Susceptibility and Early Onset of Childhood Acute Lymphoblastic Leukemia.miR-196a-2 基因型决定儿童急性淋巴细胞白血病的易感性和发病年龄。
Anticancer Res. 2020 Aug;40(8):4465-4469. doi: 10.21873/anticanres.14451.
6
LncRNA MEG3 rs3087918 was associated with a decreased breast cancer risk in a Chinese population: a case-control study.长链非编码 RNA MEG3 rs3087918 与中国人群乳腺癌风险降低相关：一项病例对照研究。
BMC Cancer. 2020 Jul 15;20(1):659. doi: 10.1186/s12885-020-07145-0.
7
Association analyses of a genetic variant in long non-coding RNA MEG3 with breast cancer susceptibility and serum MEG3 expression level in the Egyptian population.长链非编码 RNA MEG3 中的遗传变异与乳腺癌易感性及埃及人群血清 MEG3 表达水平的关联分析。
Cancer Biomark. 2020;28(1):49-63. doi: 10.3233/CBM-191072.
8
Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance.非编码 RNA 网络在白血病进展、转移和耐药中的作用。
Mol Cancer. 2020 Mar 12;19(1):57. doi: 10.1186/s12943-020-01175-9.
9
Significant Association Between the MiR146a Genotypes and Susceptibility to Childhood Acute Lymphoblastic Leukemia in Taiwan.miR146a 基因型与台湾儿童急性淋巴细胞白血病易感性的显著相关性
Cancer Genomics Proteomics. 2020 Mar-Apr;17(2):175-180. doi: 10.21873/cgp.20178.
10
Association of LncRNA MEG3 polymorphisms with efficacy of neoadjuvant chemotherapy in breast cancer.长链非编码 RNA MEG3 多态性与乳腺癌新辅助化疗疗效的关系。
BMC Cancer. 2019 Sep 5;19(1):877. doi: 10.1186/s12885-019-6077-3.

长链非编码 RNA 基因型对儿童白血病风险预测的新贡献

Novel Contribution of Long Non-coding RNA Genotype to Prediction of Childhood Leukemia Risk.

机构信息

Department of Pediatrics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C.

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.

出版信息

Cancer Genomics Proteomics. 2022 Jan-Feb;19(1):27-34. doi: 10.21873/cgp.20301.

DOI:10.21873/cgp.20301
PMID:34949657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8717951/
Abstract

BACKGROUND/AIM: Acute lymphoblastic leukemia (ALL) is frequent among children. Few studies have researched the relationship between maternally expressed gene 3 (MEG3) and cancer risk. We hypothesized long non-coding RNA MEG3 polymorphisms might influence the risk of childhood ALL.

MATERIALS AND METHODS

In a total of 266 patients with childhood ALL and 266 healthy controls, genotypes of MEG3 rs7158663, rs3087918, rs11160608 and rs4081134 single nucleotide polymorphisms were investigated for their associations with childhood ALL.

RESULTS

MEG3 rs7158663 AG and AA genotypes were significantly associated with ALL [odds ratio=1.61 (95% confidence interval=1.12-2.31) and 2.21 (1.16-4.22), respectively]. The A allele also exhibited a statistical association with higher risk of ALL (p=0.0015). There was no positive association as for rs3087918, rs11160608 or rs4081134. Interestingly, a significant interaction between MEG3 rs7158663 and age (≥3.5 years) and gender (male) was found.

CONCLUSION

MEG3 rs7158663 AG/AA genotypes were associated with higher susceptibility to childhood ALL. These novel findings should be validated in larger populations and different ethnicities.

摘要

背景/目的：急性淋巴细胞白血病（ALL）在儿童中较为常见。很少有研究探讨母源表达基因 3（MEG3）与癌症风险之间的关系。我们假设长非编码 RNA MEG3 多态性可能影响儿童 ALL 的风险。

材料和方法

在 266 例儿童 ALL 患者和 266 例健康对照者中，研究了 MEG3 rs7158663、rs3087918、rs11160608 和 rs4081134 单核苷酸多态性的基因型与儿童 ALL 之间的关系。

结果

MEG3 rs7158663 AG 和 AA 基因型与 ALL 显著相关[比值比=1.61（95%置信区间=1.12-2.31）和 2.21（1.16-4.22）]。A 等位基因也与 ALL 的发病风险呈统计学相关（p=0.0015）。rs3087918、rs11160608 或 rs4081134 与 ALL 无明显相关性。有趣的是，MEG3 rs7158663 与年龄（≥3.5 岁）和性别（男性）之间存在显著的交互作用。

结论

MEG3 rs7158663 AG/AA 基因型与儿童 ALL 的易感性增加相关。这些新发现应在更大的人群和不同的种族中进行验证。