Backman Katri, Helminen Merja, Kekäläinen Eliisa, Mikkola Ilona, Nieminen Tea, Nuolivirta Kirsi, Peltola Ville, Seuri Raija, Walle Satu-Maaria, Ruuska-Loewald Terhi
Department of Paediatrics, Kuopio University Hospital, Kuopio, Finland.
Department of Clinical medicine, University of Eastern Finland, Kuopio, Finland.
Acta Paediatr. 2025 Feb;114(2):248-257. doi: 10.1111/apa.17481. Epub 2024 Nov 1.
The first evidence-based Finnish guidelines for paediatric lower respiratory tract infections (LRTIs) were published in 2014 and completely updated in 2023. This paper, by the interdisciplinary working group that developed the 2023 guidelines, summarises the main recommendations.
The 2023 guidelines were produced after a systematic review. Strong evidence was at least two separate, high-quality studies, moderate evidence was at least one high-quality study and weak evidence was at least one satisfactory study. The authors have now summarised the key points.
There was strong evidence that antitussives and beta-sympathomimetics were not effective for bronchitis-related cough and that laryngitis should be treated with oral corticosteroids, with adrenaline inhalations added in severe cases. Also, that amoxicillin for 5 days provided sufficient treatment for paediatric community-acquired pneumonia and that children with apparent viral pneumonia could be observed without antimicrobial therapy. There was moderate evidence that corticosteroids or inhaled agents were not effective for bronchiolitis and that administering salbutamol with a holding chamber could relieve symptoms of wheezing bronchitis. Also, pertussis should be considered for unvaccinated infants with coughs.
The 2023 guidelines aim to improve acute evidence-based treatment of LRTIs, through appropriate antibiotics, inhaled drugs, corticosteroids, radiology and laboratory testing.
基于证据的首份芬兰小儿下呼吸道感染(LRTIs)指南于2014年发布,并于2023年全面更新。本文由制定2023年指南的跨学科工作组撰写,总结了主要建议。
2023年指南是在系统评价后制定的。有力证据至少来自两项独立的高质量研究,中等证据至少来自一项高质量研究,薄弱证据至少来自一项令人满意的研究。作者现总结了要点。
有力证据表明,镇咳药和β-拟交感神经药对支气管炎相关咳嗽无效,喉炎应采用口服皮质类固醇治疗,严重病例可加用肾上腺素吸入剂。此外,5天的阿莫西林治疗足以治愈小儿社区获得性肺炎,明显患有病毒性肺炎的儿童可不进行抗菌治疗。中等证据表明,皮质类固醇或吸入剂对细支气管炎无效,使用储雾罐给予沙丁胺醇可缓解喘息性支气管炎症状。此外,未接种疫苗且咳嗽的婴儿应考虑百日咳。
2023年指南旨在通过适当使用抗生素、吸入药物、皮质类固醇、放射学和实验室检测,改善LRTIs的急性循证治疗。