Kuppuswamy Annapoorna
School of Biomedical Sciences, University of Leeds, Leeds, UK.
J Physiol. 2025 Feb;603(3):759-772. doi: 10.1113/JP285900. Epub 2024 Nov 2.
Post-stroke fatigue is a chronic problem with significant impact on morbidity and mortality, which urgently needs effective treatments. The last decade has seen a considerable increase in interest in understanding the pathophysiology of fatigue and developing treatments. In this review, following a summary of theoretical frameworks to understand chronic fatigue, I make a case for why phenotyping fatigue is a necessary step to fully understand pathophysiology, which in turn is essential for the development of robust treatments. I then appraise current post-stroke fatigue literature with the view of identifying post-stroke fatigue phenotypes.
中风后疲劳是一个对发病率和死亡率有重大影响的慢性问题，迫切需要有效的治疗方法。在过去十年中，人们对了解疲劳的病理生理学和开发治疗方法的兴趣显著增加。在这篇综述中，在总结了理解慢性疲劳的理论框架之后，我阐述了为什么对疲劳进行表型分析是充分理解病理生理学的必要步骤，而这反过来对于开发强有力的治疗方法至关重要。然后，我评估了当前关于中风后疲劳的文献，以期确定中风后疲劳的表型。
