So Jisun, Yao Jonathan H, Magadmi Rozana, Matthan Nirupa R, Lamon-Fava Stefania
Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA; Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA; Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
Prostaglandins Leukot Essent Fatty Acids. 2024 Apr;203:102655. doi: 10.1016/j.plefa.2024.102655. Epub 2024 Oct 29.
The rate of cardiovascular disease (CVD) death is higher in men than women before age 50 y, but the gap between sexes significantly narrows after menopause. Lipid mediators derived from EPA, DHA and AA play a role in inflammation and CVD. The aim of our study was to assess whether plasma concentrations of these lipid mediators differ between postmenopausal women and men. Twelve postmenopausal women and 9 men with low-grade chronic inflammation completed a randomized, double-blind, crossover study consisting of a 4-week lead-in placebo phase (3 g/d high-oleic acid sunflower oil) followed by randomization to either 3 g/d DHA or 3 g/d EPA for 10 weeks and crossover for additional 10 weeks, separated by a washout phase. Plasma phospholipid content of EPA, DHA and AA and plasma concentrations of their derived lipid mediators were measured at the end of the placebo lead-in phase (baseline) and the DHA and EPA supplementation phases. There were no sex differences in plasma phospholipid EPA, DHA and AA at baseline and after DHA and EPA supplementation. However, plasma concentrations of lipid mediators derived from EPA, DHA and AA via 15-lipoxygenase were lower in postmenopausal women than men, especially after supplementation. Sex differences in EPA- and DHA-derived lipid mediators with anti-inflammatory and pro-resolving actions may partly explain the faster rise in CVD in postmenopausal women than age-matched men.
在50岁之前，男性心血管疾病（CVD）的死亡率高于女性，但绝经后两性之间的差距显著缩小。源自二十碳五烯酸（EPA）、二十二碳六烯酸（DHA）和花生四烯酸（AA）的脂质介质在炎症和心血管疾病中起作用。我们研究的目的是评估绝经后女性和男性之间这些脂质介质的血浆浓度是否存在差异。12名绝经后女性和9名患有低度慢性炎症的男性完成了一项随机、双盲、交叉研究，该研究包括为期4周的导入安慰剂阶段（3克/天的高油酸向日葵油），随后随机分为3克/天的DHA或3克/天的EPA，持续10周，并交叉再进行10周，中间有一个洗脱期。在安慰剂导入阶段（基线）以及DHA和EPA补充阶段结束时，测量血浆中EPA、DHA和AA的磷脂含量及其衍生脂质介质的血浆浓度。在基线以及DHA和EPA补充后，血浆磷脂中的EPA、DHA和AA不存在性别差异。然而，绝经后女性中通过15-脂氧合酶由EPA、DHA和AA衍生的脂质介质的血浆浓度低于男性，尤其是在补充后。具有抗炎和促消退作用的源自EPA和DHA的脂质介质的性别差异可能部分解释了绝经后女性心血管疾病的发病率比年龄匹配的男性上升得更快的原因。
