Li Pei-Long, Fu Hong-Min, Liu Kai, Yang Jia-Wu, Liao Yuan, Li Feng
Kunming Children's Hospital & Children's Hospital Affiliated to Kunming Medical University, Kunming Medical University, Kunming, P.R. China.
Department of Pulmonary and Critical Care Medicine, Kunming Children's Hospital, Kunming Medical University, Kunming, P.R. China.
Lipids Health Dis. 2025 Mar 27;24(1):115. doi: 10.1186/s12944-025-02535-4.
Alterations in lipid metabolic pathways constitute a pivotal characteristic of Steroid-Sensitive Nephrotic Syndrome (SSNS). Despite the significance, there has been scant exploration into the influence of polyunsaturated fatty acids (PUFAs) on metabolic syndrome (MetS) in children with SSNS. This study endeavors to elucidate the association between PUFAs and MetS in this specific pediatric population.
This study enrolled a total of 185 children aged 0-7 years with SSNS between May 2023 and May 2024. Based on international guidelines for MetS, patients were classified into a MetS group (n = 73) and a non-MetS group (n = 112). A healthy control group (n = 82) was also established. Surveys, anthropometric measurements, and blood samples were used to assess lipid profiles, glucose, insulin, and Hemoglobin A1C (HbA1C). The concentrations of serum PUFAs were quantitatively analyzed utilizing gas chromatography-mass spectrometry (GC-MS) techniques.
The MetS group exhibited significantly elevated levels of fasting blood glucose, triglyceride (TG), low-density lipoprotein (LDL) cholesterol, HbA1C, insulin, the ratio of TG to high-density lipoprotein (HDL) cholesterol, and the ratio of total cholesterol to HDL cholesterol compared to the non-MetS group. Significant differences were observed among healthy controls, MetS group, and non-MetS group in terms of ω-3 alpha-linolenic acid (ALA), ω-3 docosahexaenoic acid (DHA), ω-6 arachidonic acid, and ω-6 to ω-3 ratio.
High ω-6 arachidonic acid, ω-6/ω-3 ratio and low ω-3 ALA and ω-3 DHA were associated with elevated TG levels. An elevation in TG concentrations among pediatric patients with SSNS may have been implicated to MetS.
脂质代谢途径的改变是类固醇敏感性肾病综合征（SSNS）的一个关键特征。尽管其具有重要意义，但关于多不饱和脂肪酸（PUFAs）对SSNS患儿代谢综合征（MetS）的影响却鲜有研究。本研究旨在阐明该特定儿科人群中PUFAs与MetS之间的关联。
本研究在2023年5月至2024年5月期间共纳入185名0至7岁的SSNS患儿。根据MetS的国际指南，将患者分为MetS组（n = 73）和非MetS组（n = 112）。还设立了一个健康对照组（n = 82）。通过调查、人体测量和血液样本评估血脂谱、血糖、胰岛素和糖化血红蛋白（HbA1C）。利用气相色谱 - 质谱（GC - MS）技术对血清PUFAs的浓度进行定量分析。
与非MetS组相比，MetS组的空腹血糖、甘油三酯（TG）、低密度脂蛋白（LDL）胆固醇、HbA1C、胰岛素、TG与高密度脂蛋白（HDL）胆固醇的比值以及总胆固醇与HDL胆固醇的比值显著升高。在健康对照组、MetS组和非MetS组之间，ω - 3α - 亚麻酸（ALA）、ω - 3二十二碳六烯酸（DHA）、ω - 6花生四烯酸以及ω - 6与ω - 3的比值存在显著差异。
高ω - 6花生四烯酸、ω - 6/ω - 3比值以及低ω - 3 ALA和ω - 3 DHA与TG水平升高有关。SSNS患儿中TG浓度的升高可能与MetS有关。
