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酒精的摄入量有安全限度吗?

Is there a safe limit for consumption of alcohol?

作者信息

Musto Jessica Ann, Brown Randall, Lucey Michael Ronan

机构信息

Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

Department of Family Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

出版信息

J Hepatol. 2025 Mar;82(3):535-540. doi: 10.1016/j.jhep.2024.10.024. Epub 2024 Nov 1.

DOI:10.1016/j.jhep.2024.10.024
PMID:39489179
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11830546/
Abstract

In order to understand and curb the harms related to alcohol, it will be necessary to think beyond patterns of use that meet criteria for a diagnosis of alcohol use disorder or addiction. Current research suggests that regular daily alcohol use does not confer a health benefit, and, for many persons, even relatively low consumption is associated with a health risk. Determining a safe limit for alcohol consumption is challenging both for the individual person and for society. We conclude that excessive drinking is always risky. We provide a list of circumstances, such as chronic illness, driving a vehicle, or pregnancy where persons should be advised to abstain from alcohol. We recognise the need to encourage less consumption of alcohol, particularly in young adults and older adults with co-morbid conditions (especially if taking multiple medications). Finally, we offer the modest proposal that, for persons without the contributing negative influences described above, consumption which adheres to one drink per session, with interspersed abstinent days, does not constitute a meaningful risk to health.

摘要

为了理解并遏制与酒精相关的危害,有必要超越符合酒精使用障碍或成瘾诊断标准的使用模式去思考。当前研究表明,日常规律饮酒并无健康益处,而且对许多人来说,即使相对少量饮酒也与健康风险相关。确定酒精消费的安全限度对个人和社会而言都具有挑战性。我们得出结论,过度饮酒始终存在风险。我们列出了一些情形,比如患有慢性病、驾驶车辆或怀孕,在这些情况下应建议人们戒酒。我们认识到有必要鼓励减少酒精消费,尤其是在年轻人以及患有合并症的老年人中(特别是正在服用多种药物的情况下)。最后,我们提出一个适度的建议,对于没有上述不利影响因素的人来说,每次饮酒一杯且穿插有戒酒日的饮酒行为,对健康不构成重大风险。

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本文引用的文献

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Alcohol Consumption Patterns and Mortality Among Older Adults With Health-Related or Socioeconomic Risk Factors.有健康相关或社会经济风险因素的老年人的饮酒模式和死亡率。
JAMA Netw Open. 2024 Aug 1;7(8):e2424495. doi: 10.1001/jamanetworkopen.2024.24495.
2
Excessive Alcohol Use and Alcohol Use Disorders: A Policy Brief of the American College of Physicians.过量饮酒与酒精使用障碍:美国医师学院政策简讯。
Ann Intern Med. 2024 May;177(5):656-657. doi: 10.7326/M23-3434. Epub 2024 Apr 23.
3
Alcohol-associated liver disease-Global epidemiology.酒精性肝病——全球流行病学
Hepatology. 2024 Dec 1;80(6):1307-1322. doi: 10.1097/HEP.0000000000000899. Epub 2024 Apr 19.
4
Minimum unit pricing for alcohol saves lives, so why is it not implemented more widely?酒精最低单位定价能挽救生命,那么为何没有更广泛地实施呢?
BMJ. 2024 Mar 12;384:e077550. doi: 10.1136/bmj-2023-077550.
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Impact of Longitudinal Alcohol Use Patterns on Long-Term Risk of Cirrhosis Among US Veterans With Steatotic Liver Disease.纵向饮酒模式对伴有脂肪性肝病的美国退伍军人长期肝硬化风险的影响。
Gastroenterology. 2024 Jun;166(6):1156-1165.e4. doi: 10.1053/j.gastro.2024.02.032. Epub 2024 Feb 29.
6
Deaths from Excessive Alcohol Use - United States, 2016-2021.2016-2021 年美国因过量饮酒导致的死亡人数。
MMWR Morb Mortal Wkly Rep. 2024 Feb 29;73(8):154-161. doi: 10.15585/mmwr.mm7308a1.
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Evaluating the impact of minimum unit pricing for alcohol in Scotland: a theory-based synthesis of the evidence.评估苏格兰酒类最低单位定价的影响:基于理论的证据综合分析。
Lancet. 2023 Nov;402 Suppl 1:S14. doi: 10.1016/S0140-6736(23)02065-2.
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Association Between Daily Alcohol Intake and Risk of All-Cause Mortality: A Systematic Review and Meta-analyses.每日饮酒量与全因死亡率风险的关联:系统评价和荟萃分析。
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J Hepatol. 2023 Mar;78(3):501-512. doi: 10.1016/j.jhep.2022.11.013. Epub 2022 Nov 22.