Liu Xingyue, Deng Wen, Yang Yuzhou, Xi Jianfeng, Li Sijie, Zhang Lei, Li Peng, Wu Weibing
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, China.
Key Laboratory for Organic Electronics and Information, National Jiangsu Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China.
Int J Biol Macromol. 2024 Dec;282(Pt 4):137171. doi: 10.1016/j.ijbiomac.2024.137171. Epub 2024 Nov 1.
Flexible surface-enhanced Raman scattering (SERS) substrates that provide simple sampling are helpful for the on-site detection of explosive contamination, pesticide residues on food surfaces, and water pollution in public spaces. Using superhydrophobic nanocellulose-based film as the support, 2D flexible SERS substrates that integrated sampling, enrichment, and detection were successfully fabricated via the solvent-induced evaporation method. This approach enabled the co-loading of two plasmonic nanoparticles with different sizes and shapes. A uniform and dense distribution of two-dimensional "hot spots" was created by the plasmonic nanoparticles' self-assembly on the hydrophobic substrate. By adjusting the loading ratio of Au-core/Ag-shell nanocubes and gold nanospheres, their synergistic effect optimized the "hot spots" structure and significantly increased the SERS signal intensity. Additionally, the hydrophobic property of the substrate allowed the target analytes to be concentrated throughout the drying process, significantly increasing the sensitivity of SERS detection. This flexible substrate can sensitively and accurately detect the pesticide residues of phosphorus and methyl parathion on apple peel with the detection limit of 10 g/L and relative standard deviation (RSD) less than 10 %. The high-performance SERS substrate has great potential for in-situ detection applications such as food safety and environmental monitoring.
提供简单采样的柔性表面增强拉曼散射（SERS）基底有助于现场检测爆炸物污染、食品表面的农药残留以及公共场所的水污染。以超疏水纳米纤维素基薄膜为支撑体，通过溶剂诱导蒸发法成功制备了集成采样、富集和检测功能的二维柔性SERS基底。这种方法能够共负载两种不同尺寸和形状的等离子体纳米颗粒。通过等离子体纳米颗粒在疏水基底上的自组装，形成了均匀且密集分布的二维“热点”。通过调整金核/银壳纳米立方体和金纳米球的负载比例，它们的协同效应优化了“热点”结构并显著提高了SERS信号强度。此外，基底的疏水性使得目标分析物在整个干燥过程中得以浓缩，显著提高了SERS检测的灵敏度。这种柔性基底能够灵敏且准确地检测苹果皮上的磷和甲基对硫磷农药残留，检测限为10 μg/L，相对标准偏差（RSD）小于10%。这种高性能的SERS基底在食品安全和环境监测等原位检测应用中具有巨大潜力。
