Ahmed Idris Adewale, Zamakshshari Nor Hisam, Mikail Maryam Abimbola, Bello Ibrahim, Hossain Md Sanower
Department of Biotechnology, Faculty of Applied Science, Lincoln University College, 47301 Petaling Jaya, Selangor, Malaysia; Mimia Sdn. Bhd., Selangor, Malaysia.
Department of Chemistry, Faculty of Resource Science and Technology, University Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia.
Fitoterapia. 2025 Jan;180:106282. doi: 10.1016/j.fitote.2024.106282. Epub 2024 Nov 1.
Cellular senescence, the irreversible arrest of cell division, is a hallmark of aging and a key contributor to age-related disorders. Targeting senescent cells represents a promising therapeutic approach to combat these ailments. This review explores the potential of Garcinia species, a genus rich in flavonoids with established antioxidant and anti-inflammatory properties, as a source of natural anti-senescence agents. We investigate the intricate connections between aging, cellular senescence, and oxidative stress, highlighting the detrimental effects of free radicals on cellular health. Furthermore, we analyze the diverse array of flavonoids identified within Garcinia and their established cellular mechanisms. We critically evaluate the emerging evidence for the anti-senescence potential of flavonoids in general and the limited research on Garcinia flavonoids in this context. By identifying existing knowledge gaps and paving the way for future research, this review underscores the exciting potential of Garcinia flavonoids as natural anti-senescence agents. These agents hold promise for not only promoting healthy aging but also for the development of cosmeceutical products that combat the visible signs of aging.
细胞衰老，即细胞分裂的不可逆停滞，是衰老的一个标志，也是与年龄相关疾病的关键促成因素。靶向衰老细胞是对抗这些疾病的一种有前景的治疗方法。本综述探讨了藤黄属植物作为天然抗衰老剂来源的潜力，该属植物富含具有抗氧化和抗炎特性的黄酮类化合物。我们研究了衰老、细胞衰老和氧化应激之间的复杂联系，强调了自由基对细胞健康的有害影响。此外，我们分析了藤黄属植物中鉴定出的各种黄酮类化合物及其既定的细胞机制。我们批判性地评估了黄酮类化合物一般抗衰老潜力的新证据，以及在此背景下对藤黄属黄酮类化合物的有限研究。通过识别现有知识空白并为未来研究铺平道路，本综述强调了藤黄属黄酮类化合物作为天然抗衰老剂的令人兴奋的潜力。这些制剂不仅有望促进健康衰老，还能用于开发对抗衰老可见迹象的药妆产品。
