Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Taipei City 112201, Taiwan; Department of Laboratories, Philippine General Hospital, Taft Avenue, Ermita, Manila, 1000 Metro Manila, Philippines.
Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Taipei City 112201, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Road, Taipei City 112304, Taiwan.
Surg Pathol Clin. 2024 Dec;17(4):587-597. doi: 10.1016/j.path.2024.07.008. Epub 2024 Aug 17.
:AFF2 carcinoma is an emerging entity of the sinonasal tract and skull base, commonly exhibiting exophytic and endophytic papillary growth, complex anastomosing trabeculae, monotonous cytomorphology, acantholytic change, and tumor-infiltrating neutrophils. A subset displays overt infiltration and high-grade features akin to non-keratinizing squamous cell carcinoma. Glandular differentiation may also be rarely present. The tumor shows frequent local recurrence and occasional distant metastasis. An accurate diagnosis requires the recognition of these key histologic features, followed by molecular confirmation. Recently, AFF2 immunohistochemistry has been demonstrated to be a sensitive and specific ancillary marker. This comprehensive review summarizes the current understanding of DEK::AFF2 carcinoma.
:AFF2 型癌是一种新出现的发生于鼻窦和颅底的肿瘤，通常表现为外生性和内生性的乳头状生长、复杂的吻合小梁、单一的细胞形态、棘层松解性改变和肿瘤浸润性中性粒细胞。有一部分病例表现为明显的浸润性和类似于非角化性鳞状细胞癌的高级别特征。偶尔也会出现腺分化。该肿瘤具有较高的局部复发率和偶尔的远处转移率。准确的诊断需要识别这些关键的组织学特征，然后通过分子检测进行确认。最近，AFF2 的免疫组化已被证明是一种敏感且特异的辅助标志物。本文全面总结了目前对 DEK::AFF2 型癌的认识。
