• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

未使用生长激素或氧雄龙的巴西特纳综合征女孩的生长曲线

Growth charts of Brazilian girls with Turner syndrome without the use of GH or oxandrolone.

作者信息

Carpini-Dantas Stela, Guerra-Junior Gil, Maciel-Guerra Andréa Trevas, Marmo Denise Barbieri, Vieira Tarsis Paiva, Lopes Carolina Paniago, Baptista Maria Tereza Matias, Morcillo André Moreno, de Lemos-Marini Sofia Helena Valente

机构信息

Departamento de Pediatria da Divisão de Endocrinologia Pediátrica, Universidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas (FCM), Campinas, São Paulo, Brazil.

Departamento de Pediatria da Divisão de Endocrinologia Pediátrica, Universidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas (FCM), Campinas, São Paulo, Brazil.

出版信息

J Pediatr (Rio J). 2025 Mar-Apr;101(2):231-237. doi: 10.1016/j.jped.2024.09.003. Epub 2024 Oct 25.

DOI:10.1016/j.jped.2024.09.003
PMID:39489927
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11889696/
Abstract

OBJECTIVE

The development of specific growth charts for Turner Syndrome (TS) promotes adequate assessment of growth and weight gain, and earlier diagnosis of comorbidities, and may help to analyze the effectiveness of treatments to promote growth and puberty. The aim of this study was to construct a growth chart with the largest possible series of patients with a cytogenetic diagnosis of TS from a Brazilian reference center.

METHODS

This is a longitudinal study, with 259 cases of TS born between 1957 and 2014 and followed between 1975 and 2019, without the use of GH or oxandrolone. 3,160 height measurements and 2,918 wt measurements were used, with subsequent calculation of the Body Mass Index (BMI). For data analysis, the "GAMLSS" package of the "R" software was used.

RESULTS

The mean target height was 157.8 cm (standard deviation 5.2; median 160.4 cm). The mean height of patients with TS at 20 years of age was 145.6 cm (standard deviation 5.9; median 146.7 cm). Height, weight, and BMI by age graphs were developed for TS girls between 2 and 20 years.

CONCLUSION

These growth charts may be used to monitor the growth of girls with TS and to verify the effect of adjuvant treatments on promoting growth.

摘要

目的

制定特纳综合征（TS）的特定生长图表有助于对生长和体重增加进行充分评估，更早诊断合并症，还可能有助于分析促进生长和青春期治疗的效果。本研究的目的是利用巴西一家参考中心尽可能多的经细胞遗传学诊断为TS的患者构建生长图表。

方法

这是一项纵向研究，纳入了1957年至2014年出生、在1975年至2019年期间接受随访的259例TS患者，这些患者未使用生长激素（GH）或氧雄龙。共使用了3160次身高测量值和2918次体重测量值，并随后计算了体重指数（BMI）。数据分析使用了“R”软件的“GAMLSS”包。

结果

平均目标身高为157.8厘米（标准差5.2；中位数160.4厘米）。TS患者20岁时的平均身高为145.6厘米（标准差5.9；中位数146.7厘米）。绘制了2至20岁TS女孩按年龄划分的身高、体重和BMI图表。

结论

这些生长图表可用于监测TS女孩的生长情况，并验证辅助治疗对促进生长的效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dbb/11889696/2fb64e6e55c6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dbb/11889696/09ff3026ee53/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dbb/11889696/3c988ecce1a0/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dbb/11889696/2fb64e6e55c6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dbb/11889696/09ff3026ee53/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dbb/11889696/3c988ecce1a0/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dbb/11889696/2fb64e6e55c6/gr3.jpg

相似文献

1
Growth charts of Brazilian girls with Turner syndrome without the use of GH or oxandrolone.未使用生长激素或氧雄龙的巴西特纳综合征女孩的生长曲线
J Pediatr (Rio J). 2025 Mar-Apr;101(2):231-237. doi: 10.1016/j.jped.2024.09.003. Epub 2024 Oct 25.
2
Growth curves for Turkish Girls with Turner Syndrome: Results of the Turkish Turner Syndrome Study Group.土耳其特纳综合征女孩的生长曲线：土耳其特纳综合征研究组的结果。
J Clin Res Pediatr Endocrinol. 2015 Sep;7(3):183-91. doi: 10.4274/jcrpe.2023.
3
Normalization of puberty and adult height in girls with Turner syndrome: results of the Swedish Growth Hormone trials initiating transition into adulthood.特纳综合征女童青春期和成人身高的正常化：启动成年期过渡的瑞典生长激素试验结果。
Front Endocrinol (Lausanne). 2023 Jul 17;14:1197897. doi: 10.3389/fendo.2023.1197897. eCollection 2023.
4
Oxandrolone for growth hormone-treated girls aged up to 18 years with Turner syndrome.氧雄龙用于治疗18岁及以下患有特纳综合征且接受生长激素治疗的女孩。
Cochrane Database Syst Rev. 2019 Oct 30;2019(10):CD010736. doi: 10.1002/14651858.CD010736.pub2.
5
Prospective study confirms oxandrolone-associated improvement in height in growth hormone-treated adolescent girls with Turner syndrome.前瞻性研究证实，在接受生长激素治疗的特纳综合征青春期女孩中，氧雄龙可改善身高。
Horm Res Paediatr. 2011;75(1):38-46. doi: 10.1159/000317529. Epub 2010 Aug 20.
6
Efficacy and safety of oxandrolone in growth hormone-treated girls with turner syndrome.生长激素治疗特纳综合征女孩中奥沙利酮的疗效和安全性。
J Clin Endocrinol Metab. 2010 Mar;95(3):1151-60. doi: 10.1210/jc.2009-1821. Epub 2010 Jan 8.
7
New reference growth charts for Japanese girls with Turner syndrome.日本特纳综合征女孩的新参考生长图表。
Pediatr Int. 2009 Oct;51(5):709-14. doi: 10.1111/j.1442-200X.2009.02838.x. Epub 2009 Mar 27.
8
Weight gain in Turner Syndrome: association to puberty induction? - longitudinal analysis of KIGS data.特纳综合征中的体重增加：与青春期诱导有关吗？——对KIGS数据的纵向分析
Clin Endocrinol (Oxf). 2016 Jul;85(1):85-91. doi: 10.1111/cen.13044. Epub 2016 Mar 18.
9
Growth hormone therapy of Turner's syndrome: beneficial effect on adult height.特纳综合征的生长激素治疗：对成人身高的有益影响。
J Pediatr. 1998 Feb;132(2):319-24. doi: 10.1016/s0022-3476(98)70452-4.
10
Improved final height in girls with Turner's syndrome treated with growth hormone and oxandrolone.使用生长激素和氧雄龙治疗的特纳综合征女孩最终身高得到改善。
J Clin Endocrinol Metab. 1996 Feb;81(2):635-40. doi: 10.1210/jcem.81.2.8636281.

本文引用的文献

1
Akaike's Information Criterion for Stoichiometry Inference of Supramolecular Complexes.超分子配合物化学计量推断的赤池信息量准则
Angew Chem Int Ed Engl. 2023 Mar 27;62(14):e202219059. doi: 10.1002/anie.202219059. Epub 2023 Feb 23.
2
Growth in girls with Turner syndrome.特纳综合征女孩的生长情况。
Front Endocrinol (Lausanne). 2023 Jan 12;13:1068128. doi: 10.3389/fendo.2022.1068128. eCollection 2022.
3
Development of disease-specific growth charts in Turner syndrome and Noonan syndrome.特纳综合征和努南综合征中疾病特异性生长曲线的制定。
Ann Pediatr Endocrinol Metab. 2017 Dec;22(4):240-246. doi: 10.6065/apem.2017.22.4.240. Epub 2017 Dec 31.
4
Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting.特纳综合征患者护理临床实践指南：2016 年辛辛那提国际特纳综合征会议纪要。
Eur J Endocrinol. 2017 Sep;177(3):G1-G70. doi: 10.1530/EJE-17-0430.
5
Growth curves for girls with Turner syndrome.特纳综合征女孩的生长曲线。
Biomed Res Int. 2014;2014:687978. doi: 10.1155/2014/687978. Epub 2014 May 15.
6
Spontaneous puberty in girls with early diagnosis of Turner syndrome.特纳综合征早期诊断女孩的自然青春期。
Arq Bras Endocrinol Metabol. 2012 Dec;56(9):653-7. doi: 10.1590/s0004-27302012000900009.
7
[The inclusion of new techniques of chromosome analysis has improved the cytogenetic profile of Turner syndrome].[染色体分析新技术的纳入改善了特纳综合征的细胞遗传学特征]
Arq Bras Endocrinol Metabol. 2009 Dec;53(9):1137-42. doi: 10.1590/s0004-27302009000900010.
8
New reference growth charts for Japanese girls with Turner syndrome.日本特纳综合征女孩的新参考生长图表。
Pediatr Int. 2009 Oct;51(5):709-14. doi: 10.1111/j.1442-200X.2009.02838.x. Epub 2009 Mar 27.
9
Spontaneous final height in Turner's syndrome in Brazil.巴西特纳综合征患者的自然终身高
J Pediatr Endocrinol Metab. 2007 Nov;20(11):1207-14. doi: 10.1515/jpem.2007.20.11.1207.
10
Care of girls and women with Turner syndrome: a guideline of the Turner Syndrome Study Group.特纳综合征女性患者的护理：特纳综合征研究组指南
J Clin Endocrinol Metab. 2007 Jan;92(1):10-25. doi: 10.1210/jc.2006-1374. Epub 2006 Oct 17.