未使用生长激素或氧雄龙的巴西特纳综合征女孩的生长曲线
Growth charts of Brazilian girls with Turner syndrome without the use of GH or oxandrolone.
作者信息
Carpini-Dantas Stela, Guerra-Junior Gil, Maciel-Guerra Andréa Trevas, Marmo Denise Barbieri, Vieira Tarsis Paiva, Lopes Carolina Paniago, Baptista Maria Tereza Matias, Morcillo André Moreno, de Lemos-Marini Sofia Helena Valente
机构信息
Departamento de Pediatria da Divisão de Endocrinologia Pediátrica, Universidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas (FCM), Campinas, São Paulo, Brazil.
Departamento de Pediatria da Divisão de Endocrinologia Pediátrica, Universidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas (FCM), Campinas, São Paulo, Brazil.
出版信息
J Pediatr (Rio J). 2025 Mar-Apr;101(2):231-237. doi: 10.1016/j.jped.2024.09.003. Epub 2024 Oct 25.
OBJECTIVE
The development of specific growth charts for Turner Syndrome (TS) promotes adequate assessment of growth and weight gain, and earlier diagnosis of comorbidities, and may help to analyze the effectiveness of treatments to promote growth and puberty. The aim of this study was to construct a growth chart with the largest possible series of patients with a cytogenetic diagnosis of TS from a Brazilian reference center.
METHODS
This is a longitudinal study, with 259 cases of TS born between 1957 and 2014 and followed between 1975 and 2019, without the use of GH or oxandrolone. 3,160 height measurements and 2,918 wt measurements were used, with subsequent calculation of the Body Mass Index (BMI). For data analysis, the "GAMLSS" package of the "R" software was used.
RESULTS
The mean target height was 157.8 cm (standard deviation 5.2; median 160.4 cm). The mean height of patients with TS at 20 years of age was 145.6 cm (standard deviation 5.9; median 146.7 cm). Height, weight, and BMI by age graphs were developed for TS girls between 2 and 20 years.
CONCLUSION
These growth charts may be used to monitor the growth of girls with TS and to verify the effect of adjuvant treatments on promoting growth.
目的
制定特纳综合征（TS）的特定生长图表有助于对生长和体重增加进行充分评估，更早诊断合并症，还可能有助于分析促进生长和青春期治疗的效果。本研究的目的是利用巴西一家参考中心尽可能多的经细胞遗传学诊断为TS的患者构建生长图表。
方法
这是一项纵向研究，纳入了1957年至2014年出生、在1975年至2019年期间接受随访的259例TS患者，这些患者未使用生长激素（GH）或氧雄龙。共使用了3160次身高测量值和2918次体重测量值，并随后计算了体重指数（BMI）。数据分析使用了“R”软件的“GAMLSS”包。
结果
平均目标身高为157.8厘米（标准差5.2；中位数160.4厘米）。TS患者20岁时的平均身高为145.6厘米（标准差5.9；中位数146.7厘米）。绘制了2至20岁TS女孩按年龄划分的身高、体重和BMI图表。
结论
这些生长图表可用于监测TS女孩的生长情况，并验证辅助治疗对促进生长的效果。
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