Amirikia H, Savoy-Moore R T, Sundareson A S, Moghissi K S
Fertil Steril. 1986 Feb;45(2):202-8. doi: 10.1016/s0015-0282(16)49155-7.
Ten patients with female gender dysphoria were treated with exogenous androgen (testosterone [T] enanthate USP) and underwent sex reassignment surgery. Histologic changes of the ovaries of this treated group were studied and compared with those of patients with polycystic ovarian syndrome (PCO) and a normal control group. Significant differences among groups were observed for thickness of the tunica albuginea (639.8 +/- 56.5 micron, 529.2 +/- 59.3 micron, and 170.1 +/- 29.8 micron in the exogenous androgens, PCO, and normal groups, respectively), basal membrane thickness (72.8 +/- 2.8 micron, 46.2 +/- 4.2 micron, and 25.2 micron), number of cystic follicles (2.0 +/- 0.4, 5.8 +/- 0.7, and 1.8 +/- 0.8), and T and luteinizing hormone concentrations. Theca cell hyperplasia was present only in the PCO group. It is concluded that exogenous androgen can thicken the tunica albuginea and basal membrane and that these histologic changes are similar to those seen in PCO ovaries under excess endogenous androgen production.
十名女性性别焦虑症患者接受了外源性雄激素（十一酸睾酮USP）治疗，并接受了性别重置手术。研究了该治疗组卵巢的组织学变化，并与多囊卵巢综合征（PCO）患者和正常对照组进行了比较。观察到各组之间在白膜厚度（外源性雄激素组、PCO组和正常组分别为639.8±56.5微米、529.2±59.3微米和170.1±29.8微米）、基底膜厚度（72.8±2.8微米、46.2±4.2微米和25.2微米）、囊性卵泡数量（2.0±0.4、5.8±0.7和1.8±0.8）以及睾酮和促黄体生成素浓度方面存在显著差异。仅PCO组出现了卵泡膜细胞增生。结论是外源性雄激素可使白膜和基底膜增厚，且这些组织学变化与内源性雄激素分泌过多时PCO卵巢所见的变化相似。
