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鞘内疼痛泵靶向药物递送治疗恶性疼痛。

Targeted drug delivery via intrathecal pain pump for the treatment of malignant pain.

机构信息

University of Colorado, Department of Radiology Interventional Radiology Section, Aurora, CO.

Radiology Alliance Director of Radiology Summit Hospital, Hermitage, TN.

出版信息

Tech Vasc Interv Radiol. 2024 Sep;27(3):100985. doi: 10.1016/j.tvir.2024.100985. Epub 2024 Aug 24.

DOI:10.1016/j.tvir.2024.100985
PMID:39490376
Abstract

Cancer patients experience pain at significant rates but are often undertreated-it is estimated that less than 1% of eligible cancer pain patients receive appropriate targeted drug delivery to address their pain. Cancer pain is often managed with systemic opioid treatment; however, this approach is limited in treating pain adequately and carries significant side effect risk profiles. Successful treatment of pain is closely tied to better oncologic outcomes as well as better measures on assessments of quality of life for cancer patients. Placement of intrathecal pain pumps represent a safe and effective way to manage pain in cancer patients. We describe the process of placing intrathecal pain pumps in an interventional radiology suite. This method of pump placement represents a minimally invasive approach to long term and continuous pain relief. Intrathecal pain pumps help maximize pain control for patients experiencing refractory pain due to disease process or treatments associated with malignancy.

摘要

癌症患者经历疼痛的比例很高,但往往治疗不足——据估计,只有不到 1%的符合条件的癌症疼痛患者接受了适当的靶向药物治疗来缓解疼痛。癌症疼痛通常通过全身阿片类药物治疗来管理;然而,这种方法在充分治疗疼痛方面存在局限性,并且具有显著的副作用风险特征。疼痛的成功治疗与更好的肿瘤学结果以及更好的癌症患者生活质量评估措施密切相关。植入鞘内疼痛泵是管理癌症患者疼痛的一种安全有效的方法。我们描述了在介入放射学套房中放置鞘内疼痛泵的过程。这种泵放置方法是一种微创的长期持续缓解疼痛的方法。鞘内疼痛泵有助于最大限度地控制因疾病过程或与恶性肿瘤相关的治疗而导致难治性疼痛的患者的疼痛。

相似文献

1
Targeted drug delivery via intrathecal pain pump for the treatment of malignant pain.鞘内疼痛泵靶向药物递送治疗恶性疼痛。
Tech Vasc Interv Radiol. 2024 Sep;27(3):100985. doi: 10.1016/j.tvir.2024.100985. Epub 2024 Aug 24.
2
Near Death Experience from Placement of an Intrathecal Catheter.鞘内导管置入术引发的濒死体验
Pain Physician. 2016 May;19(4):E621-3.
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Systematic review of intrathecal infusion systems for long-term management of chronic non-cancer pain.鞘内输注系统用于慢性非癌性疼痛长期管理的系统评价
Pain Physician. 2009 Mar-Apr;12(2):345-60.
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Intrathecal Drug Delivery Systems for Refractory Pancreatic Cancer Pain: Observational Follow-up Study Over an 11-Year Period in a Comprehensive Cancer Center.鞘内药物输送系统治疗难治性胰腺癌疼痛:在综合癌症中心进行的 11 年观察随访研究。
Anesth Analg. 2018 Jun;126(6):2038-2046. doi: 10.1213/ANE.0000000000002903.
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Retrospective Analysis of Intrathecal Drug Delivery: Outcomes, Efficacy, and Risk for Cancer-Related Pain at a High Volume Academic Medical Center.高容量学术医学中心鞘内药物递送的回顾性分析:癌症相关疼痛的结局、疗效和风险
Neuromodulation. 2018 Oct;21(7):660-663. doi: 10.1111/ner.12759. Epub 2018 Feb 14.
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Longevity and cost of implantable intrathecal drug delivery systems for chronic pain management: a retrospective analysis of 365 patients.用于慢性疼痛管理的植入式鞘内药物输送系统的使用寿命和成本:对365例患者的回顾性分析
Neuromodulation. 2015 Feb;18(2):150-5; discussion 155-6. doi: 10.1111/ner.12235. Epub 2014 Sep 23.
7
Intrathecal opioids for intractable pain syndromes.用于顽固性疼痛综合征的鞘内注射阿片类药物。
Acta Neurochir Suppl. 2007;97(Pt 1):43-8. doi: 10.1007/978-3-211-33079-1_5.
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Intrathecal Pumps.鞘内泵。
Phys Med Rehabil Clin N Am. 2022 May;33(2):409-424. doi: 10.1016/j.pmr.2022.01.004.
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Intrathecal cervical analgesia for cancer pain: a 12-year follow-up study in a comprehensive cancer center.鞘内颈椎镇痛治疗癌症疼痛:综合癌症中心 12 年随访研究。
Reg Anesth Pain Med. 2024 Oct 8;49(10):757-763. doi: 10.1136/rapm-2023-104961.
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Intrathecal therapy for cancer and non-cancer pain.鞘内治疗癌症和非癌症疼痛。
Pain Physician. 2011 May-Jun;14(3):219-48.

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