Kardan Omid, Weigard Alexander S, Cope Lora M, Martz Meghan E, Angstadt Mike, McCurry Katherine L, Michael Cleanthis, Hardee Jillian E, Hyde Luke W, Sripada Chandra, Heitzeg Mary M
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan; Department of Psychology, University of Michigan, Ann Arbor, Michigan.
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2025 Feb;10(2):203-212. doi: 10.1016/j.bpsc.2024.10.002. Epub 2024 Oct 25.
Early substance use initiation (SUI) places youth at substantially higher risk for later substance use disorders. Furthermore, adolescence is a critical period for the maturation of brain networks, the pace and magnitude of which are susceptible to environmental influences and may shape risk for SUI.
We examined whether patterns of functional brain connectivity during rest (rsFC), measured longitudinally during pre- and early adolescence, can predict future SUI. Next, in an independent subsample, we tested whether these patterns were associated with earlier environmental exposures, specifically neighborhood pollution and socioeconomic dimensions. We utilized data from the ABCD (Adolescent Brain Cognitive Development) Study. SUI was defined as first-time use of at least 1 full dose of alcohol, nicotine, cannabis, or other drugs. We created a control group (n = 228) of participants without SUI who were matched to the SUI group (n = 233) on age, sex, race/ethnicity, household income, and parental education.
Multivariate analysis showed that whole-brain rsFC from 9-10 to 11-12 years of age (prior to SUI) prospectively differentiated the SUI and control groups. The SUI-related rsFC pattern was also related to aging in both groups, suggesting a pattern of accelerated maturation in the years prior to SUI. This same pattern of rsFC was predicted by higher pollution but not neighborhood disadvantage (adjusted for family socioeconomic factors) in an independent subsample (n = 2854).
Brain functional connectivity patterns in early adolescence that are linked to accelerated maturation can predict SUI in youth and are associated with exposure to pollution.
早期物质使用起始（SUI）会使青少年在日后患物质使用障碍的风险大幅增加。此外，青春期是脑网络成熟的关键时期，其成熟的速度和程度易受环境影响，并可能塑造SUI的风险。
我们研究了在青春期前和青春期早期纵向测量的静息状态下的脑功能连接模式（rsFC）是否能预测未来的SUI。接下来，在一个独立的子样本中，我们测试了这些模式是否与早期的环境暴露有关，特别是邻里污染和社会经济维度。我们使用了青少年大脑认知发展（ABCD）研究的数据。SUI被定义为首次使用至少一剂完整剂量的酒精、尼古丁、大麻或其他药物。我们创建了一个无SUI的对照组（n = 228），该组在年龄、性别、种族/民族、家庭收入和父母教育程度方面与SUI组（n = 233）相匹配。
多变量分析表明，9至10岁到11至12岁（在SUI之前）的全脑rsFC能够前瞻性地区分SUI组和对照组。与SUI相关的rsFC模式在两组中也与衰老有关，这表明在SUI之前的几年里存在加速成熟的模式。在一个独立子样本（n = 2854）中，较高的污染而非邻里劣势（经家庭社会经济因素调整）可预测相同的rsFC模式。
青春期早期与加速成熟相关的脑功能连接模式能够预测青少年的SUI，并与污染暴露有关。
