近期使用口服避孕药与肝静脉血栓形成的风险。一项病例对照研究。

Risk of hepatic vein thrombosis in relation to recent use of oral contraceptives. A case-control study.

作者信息

Valla D, Le M G, Poynard T, Zucman N, Rueff B, Benhamou J P

出版信息

Gastroenterology. 1986 Apr;90(4):807-11. doi: 10.1016/0016-5085(86)90855-3.

Abstract

In a case-control study, we evaluated the relative risk of hepatic vein thrombosis among recent oral contraceptive users as compared with nonusers. Thirty-three cases of hepatic vein thrombosis affecting women aged 15-45 yr were collected between 1970 and 1983, and individually matched to 3 or 4 controls interviewed in 1982-1984. There were 18 recent oral contraceptive users among the 33 cases, and 44 recent oral contraceptive users among the 128 case-matched controls. The relative risk of hepatic vein thrombosis was 2.37 (95% confidence interval: 1.05-5.34, p less than 0.02). The relative risk of hepatic vein thrombosis is close to that of stroke, myocardial infarction, and venous thromboembolism among oral contraceptive users as compared with nonusers.

摘要

在一项病例对照研究中，我们评估了近期口服避孕药使用者相较于非使用者发生肝静脉血栓形成的相对风险。1970年至1983年间收集了33例年龄在15至45岁之间的女性肝静脉血栓形成病例，并分别与1982年至1984年接受访谈的3至4名对照进行匹配。33例病例中有18名近期口服避孕药使用者，128例病例匹配对照中有44名近期口服避孕药使用者。肝静脉血栓形成的相对风险为2.37（95%置信区间：1.05 - 5.34，p小于0.02）。与非使用者相比，口服避孕药使用者发生肝静脉血栓形成的相对风险与中风、心肌梗死和静脉血栓栓塞的风险相近。